from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1262c/-

LFCtreatmentdescriptionclass of inhibitor

-1.513

Amikacinug/mL Amikacintranslation

0.725

Cap5-10ug/mL Capreomycintranslation

1.002

Rox10-50 ug/mL Roxithromycintranslation

0.269

SM2-5 ug/mL Streptomycintranslation

-1.735

Tet5-10 ug/mL Tetracyclinetranslation

-1.114

Rif0.2-5ug/mL Rifampicintranscription

-0.278

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.448

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.128

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.017

CPZ10-50 ug/mL Chlorpromazinerespiration

0.417

Clofazimine10-13 ug/mL Clofaziminerespiration

0.315

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.569

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.076

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.012

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.788

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.015

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.201

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.328

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.798

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.480

KCN5-20 ug/mL Potassium cyaniderespiration

1.207

NaN30.2-2 mM Sodium aziderespiration

1.233

Nigericin50 uM Nigericinrespiration

-0.914

TRC10-150 ug/mL Triclosanrespiration

-0.208

TRZ10-25 ug/mL Thioridazinerespiration

-0.762

Valinomycin0.5-10 uM Valinomycinrespiration

1.518

ZnSO42 mM ZnSO4respiration

1.027

menadione6-10 ug/mL Menadionerespiration

0.287

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.434

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.249

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.726

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.241

NRP_1Non-replicating persistence stage 1dosRassociated

0.795

Amp0.2mg/mL AmpicillincellWall

0.329

Cephalexin20-100 ug/mL CephalexincellWall

0.846

Cerulenin0.32-5 ug/mL CerulenincellWall

1.139

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

1.007

EMB10-20 ug/mL EthambutolcellWall

0.750

Eta12-40 ug/mL EthionamidecellWall

0.690

INH0.2-0.4 ug/mL IsoniazidcellWall

0.505

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.517

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.324

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.991

BZA0.12 mg/mL BenzamidearomaticAmides

-0.846

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.745

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.324

H2O24 mM hydrogen peroxideDNAdamaging

-0.031

Levo10 ug/mL LevofloxacinDNAdamaging

0.152

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.565

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.445

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.306

UVUV-irradiationDNAdamaging

-0.397

ARP41-4 ug/mL Antitubercular compound ARP4?

0.323

Antimycin12.5-50 ug/mL Antimycin A?

0.279

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.764

PA_110-50 ug/mL Antitubercular compound PA-1?

0.679

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.440

PA8240.2-2 ug/mL PA-824?

-1.228

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.100

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.845

Verapamil50 uM Verapamil?

1.082

mercaptoethanol2 mM 2-Mercaptoethanol?

0.397

methoxatin10-20 ug/mL Methoxatin?