from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1239c/corA

LFCtreatmentdescriptionclass of inhibitor

0.323

Amikacinug/mL Amikacintranslation

0.715

Cap5-10ug/mL Capreomycintranslation

0.640

Rox10-50 ug/mL Roxithromycintranslation

-0.392

SM2-5 ug/mL Streptomycintranslation

0.723

Tet5-10 ug/mL Tetracyclinetranslation

0.231

Rif0.2-5ug/mL Rifampicintranscription

0.451

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.268

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.949

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.941

CPZ10-50 ug/mL Chlorpromazinerespiration

1.140

Clofazimine10-13 ug/mL Clofaziminerespiration

0.818

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.322

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.769

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.290

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.087

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.104

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.047

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.175

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.370

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.833

KCN5-20 ug/mL Potassium cyaniderespiration

-0.150

NaN30.2-2 mM Sodium aziderespiration

-0.011

Nigericin50 uM Nigericinrespiration

0.552

TRC10-150 ug/mL Triclosanrespiration

2.303

TRZ10-25 ug/mL Thioridazinerespiration

1.339

Valinomycin0.5-10 uM Valinomycinrespiration

-0.475

ZnSO42 mM ZnSO4respiration

0.637

menadione6-10 ug/mL Menadionerespiration

0.493

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.594

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.161

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.501

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.184

NRP_1Non-replicating persistence stage 1dosRassociated

-0.802

Amp0.2mg/mL AmpicillincellWall

0.006

Cephalexin20-100 ug/mL CephalexincellWall

-0.042

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.104

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.323

EMB10-20 ug/mL EthambutolcellWall

0.084

Eta12-40 ug/mL EthionamidecellWall

0.032

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.220

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.817

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.749

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.916

BZA0.12 mg/mL BenzamidearomaticAmides

-0.948

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.946

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.213

H2O24 mM hydrogen peroxideDNAdamaging

-0.240

Levo10 ug/mL LevofloxacinDNAdamaging

-1.129

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.701

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.550

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.923

UVUV-irradiationDNAdamaging

2.737

ARP41-4 ug/mL Antitubercular compound ARP4?

0.528

Antimycin12.5-50 ug/mL Antimycin A?

0.176

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.054

PA_110-50 ug/mL Antitubercular compound PA-1?

0.523

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.344

PA8240.2-2 ug/mL PA-824?

-0.132

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.116

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.730

Verapamil50 uM Verapamil?

-0.485

mercaptoethanol2 mM 2-Mercaptoethanol?

0.103

methoxatin10-20 ug/mL Methoxatin?