from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1233c/-

LFCtreatmentdescriptionclass of inhibitor

-0.601

Amikacinug/mL Amikacintranslation

-0.514

Cap5-10ug/mL Capreomycintranslation

-1.111

Rox10-50 ug/mL Roxithromycintranslation

0.089

SM2-5 ug/mL Streptomycintranslation

-2.966

Tet5-10 ug/mL Tetracyclinetranslation

-0.194

Rif0.2-5ug/mL Rifampicintranscription

0.188

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.298

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.274

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.895

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.545

Clofazimine10-13 ug/mL Clofaziminerespiration

0.860

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.736

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.487

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.811

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.839

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.309

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-2.004

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.674

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.355

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.158

KCN5-20 ug/mL Potassium cyaniderespiration

0.343

NaN30.2-2 mM Sodium aziderespiration

-0.316

Nigericin50 uM Nigericinrespiration

-0.637

TRC10-150 ug/mL Triclosanrespiration

-2.009

TRZ10-25 ug/mL Thioridazinerespiration

-1.978

Valinomycin0.5-10 uM Valinomycinrespiration

0.580

ZnSO42 mM ZnSO4respiration

-0.582

menadione6-10 ug/mL Menadionerespiration

-0.414

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.461

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.184

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.260

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.720

NRP_1Non-replicating persistence stage 1dosRassociated

0.506

Amp0.2mg/mL AmpicillincellWall

0.170

Cephalexin20-100 ug/mL CephalexincellWall

0.885

Cerulenin0.32-5 ug/mL CerulenincellWall

0.720

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.338

EMB10-20 ug/mL EthambutolcellWall

0.745

Eta12-40 ug/mL EthionamidecellWall

0.673

INH0.2-0.4 ug/mL IsoniazidcellWall

0.890

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.310

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.949

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.591

BZA0.12 mg/mL BenzamidearomaticAmides

-0.108

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.391

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.148

H2O24 mM hydrogen peroxideDNAdamaging

0.317

Levo10 ug/mL LevofloxacinDNAdamaging

0.543

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.442

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.733

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.718

UVUV-irradiationDNAdamaging

-0.949

ARP41-4 ug/mL Antitubercular compound ARP4?

0.697

Antimycin12.5-50 ug/mL Antimycin A?

-0.014

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.665

PA_110-50 ug/mL Antitubercular compound PA-1?

0.369

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.133

PA8240.2-2 ug/mL PA-824?

0.998

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.984

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.543

Verapamil50 uM Verapamil?

0.091

mercaptoethanol2 mM 2-Mercaptoethanol?

0.543

methoxatin10-20 ug/mL Methoxatin?