from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1206/fadD6

LFCtreatmentdescriptionclass of inhibitor

0.488

Amikacinug/mL Amikacintranslation

-0.562

Cap5-10ug/mL Capreomycintranslation

-0.279

Rox10-50 ug/mL Roxithromycintranslation

0.841

SM2-5 ug/mL Streptomycintranslation

-0.446

Tet5-10 ug/mL Tetracyclinetranslation

0.456

Rif0.2-5ug/mL Rifampicintranscription

0.140

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.026

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.757

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.120

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.820

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.046

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.376

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.493

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.409

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.099

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.145

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.665

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.583

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.295

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.868

KCN5-20 ug/mL Potassium cyaniderespiration

-0.323

NaN30.2-2 mM Sodium aziderespiration

0.636

Nigericin50 uM Nigericinrespiration

-0.270

TRC10-150 ug/mL Triclosanrespiration

-1.192

TRZ10-25 ug/mL Thioridazinerespiration

-1.819

Valinomycin0.5-10 uM Valinomycinrespiration

0.047

ZnSO42 mM ZnSO4respiration

0.048

menadione6-10 ug/mL Menadionerespiration

-0.244

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.017

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.441

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.344

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.993

NRP_1Non-replicating persistence stage 1dosRassociated

0.280

Amp0.2mg/mL AmpicillincellWall

0.028

Cephalexin20-100 ug/mL CephalexincellWall

-0.072

Cerulenin0.32-5 ug/mL CerulenincellWall

0.091

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.031

EMB10-20 ug/mL EthambutolcellWall

0.162

Eta12-40 ug/mL EthionamidecellWall

0.017

INH0.2-0.4 ug/mL IsoniazidcellWall

0.036

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.464

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.125

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.239

BZA0.12 mg/mL BenzamidearomaticAmides

0.581

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.523

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.683

H2O24 mM hydrogen peroxideDNAdamaging

-0.100

Levo10 ug/mL LevofloxacinDNAdamaging

0.532

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.430

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.164

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.338

UVUV-irradiationDNAdamaging

0.106

ARP41-4 ug/mL Antitubercular compound ARP4?

0.127

Antimycin12.5-50 ug/mL Antimycin A?

0.644

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.499

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.227

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.723

PA8240.2-2 ug/mL PA-824?

-0.844

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.180

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.167

Verapamil50 uM Verapamil?

0.120

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.030

methoxatin10-20 ug/mL Methoxatin?