from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1204c/-

LFCtreatmentdescriptionclass of inhibitor

1.031

Amikacinug/mL Amikacintranslation

-0.277

Cap5-10ug/mL Capreomycintranslation

0.322

Rox10-50 ug/mL Roxithromycintranslation

1.238

SM2-5 ug/mL Streptomycintranslation

2.371

Tet5-10 ug/mL Tetracyclinetranslation

0.457

Rif0.2-5ug/mL Rifampicintranscription

0.496

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.800

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.151

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.070

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.787

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.624

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.759

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.223

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.178

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.793

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.044

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.178

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.603

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.393

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.064

KCN5-20 ug/mL Potassium cyaniderespiration

1.529

NaN30.2-2 mM Sodium aziderespiration

0.096

Nigericin50 uM Nigericinrespiration

-0.509

TRC10-150 ug/mL Triclosanrespiration

-1.558

TRZ10-25 ug/mL Thioridazinerespiration

-0.353

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.166

menadione6-10 ug/mL Menadionerespiration

-0.312

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.329

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.048

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.348

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.226

NRP_1Non-replicating persistence stage 1dosRassociated

0.257

Amp0.2mg/mL AmpicillincellWall

0.142

Cephalexin20-100 ug/mL CephalexincellWall

0.339

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.230

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.543

EMB10-20 ug/mL EthambutolcellWall

0.533

Eta12-40 ug/mL EthionamidecellWall

0.878

INH0.2-0.4 ug/mL IsoniazidcellWall

0.323

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.847

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.692

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.146

BZA0.12 mg/mL BenzamidearomaticAmides

0.278

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.095

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.760

H2O24 mM hydrogen peroxideDNAdamaging

0.559

Levo10 ug/mL LevofloxacinDNAdamaging

0.651

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.613

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.598

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.609

UVUV-irradiationDNAdamaging

-1.134

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.574

Antimycin12.5-50 ug/mL Antimycin A?

-0.221

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.045

PA_110-50 ug/mL Antitubercular compound PA-1?

0.173

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.132

PA8240.2-2 ug/mL PA-824?

0.176

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.053

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.553

Verapamil50 uM Verapamil?

-0.092

mercaptoethanol2 mM 2-Mercaptoethanol?

0.255

methoxatin10-20 ug/mL Methoxatin?