from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1193/fadD36

LFCtreatmentdescriptionclass of inhibitor

0.688

Amikacinug/mL Amikacintranslation

-0.013

Cap5-10ug/mL Capreomycintranslation

0.479

Rox10-50 ug/mL Roxithromycintranslation

0.895

SM2-5 ug/mL Streptomycintranslation

-1.292

Tet5-10 ug/mL Tetracyclinetranslation

0.735

Rif0.2-5ug/mL Rifampicintranscription

1.133

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.839

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.627

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.466

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.324

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.371

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.289

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-3.302

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.448

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.167

Econazole10-24 ug/mL Econazole (azole drug)respiration

2.144

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.392

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.957

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.343

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.700

KCN5-20 ug/mL Potassium cyaniderespiration

0.770

NaN30.2-2 mM Sodium aziderespiration

0.230

Nigericin50 uM Nigericinrespiration

-0.111

TRC10-150 ug/mL Triclosanrespiration

-1.648

TRZ10-25 ug/mL Thioridazinerespiration

-1.319

Valinomycin0.5-10 uM Valinomycinrespiration

0.257

ZnSO42 mM ZnSO4respiration

1.189

menadione6-10 ug/mL Menadionerespiration

0.383

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.039

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.074

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.026

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.506

NRP_1Non-replicating persistence stage 1dosRassociated

0.075

Amp0.2mg/mL AmpicillincellWall

0.262

Cephalexin20-100 ug/mL CephalexincellWall

-0.303

Cerulenin0.32-5 ug/mL CerulenincellWall

0.321

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.657

EMB10-20 ug/mL EthambutolcellWall

0.076

Eta12-40 ug/mL EthionamidecellWall

0.494

INH0.2-0.4 ug/mL IsoniazidcellWall

0.223

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.100

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.500

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.026

BZA0.12 mg/mL BenzamidearomaticAmides

-0.170

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.379

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.053

H2O24 mM hydrogen peroxideDNAdamaging

0.522

Levo10 ug/mL LevofloxacinDNAdamaging

-0.070

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.339

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.871

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.065

UVUV-irradiationDNAdamaging

1.457

ARP41-4 ug/mL Antitubercular compound ARP4?

0.446

Antimycin12.5-50 ug/mL Antimycin A?

-0.038

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.376

PA_110-50 ug/mL Antitubercular compound PA-1?

0.139

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.984

PA8240.2-2 ug/mL PA-824?

-1.177

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.191

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.277

Verapamil50 uM Verapamil?

0.158

mercaptoethanol2 mM 2-Mercaptoethanol?

0.456

methoxatin10-20 ug/mL Methoxatin?