from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1155/-

LFCtreatmentdescriptionclass of inhibitor

-0.026

Amikacinug/mL Amikacintranslation

-0.397

Cap5-10ug/mL Capreomycintranslation

-0.767

Rox10-50 ug/mL Roxithromycintranslation

-0.232

SM2-5 ug/mL Streptomycintranslation

-1.603

Tet5-10 ug/mL Tetracyclinetranslation

-2.645

Rif0.2-5ug/mL Rifampicintranscription

-0.456

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.011

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.320

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.416

CPZ10-50 ug/mL Chlorpromazinerespiration

1.074

Clofazimine10-13 ug/mL Clofaziminerespiration

0.905

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.186

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.598

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.134

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.065

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.117

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.963

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.030

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.768

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.897

KCN5-20 ug/mL Potassium cyaniderespiration

0.953

NaN30.2-2 mM Sodium aziderespiration

-0.914

Nigericin50 uM Nigericinrespiration

-0.169

TRC10-150 ug/mL Triclosanrespiration

-0.366

TRZ10-25 ug/mL Thioridazinerespiration

-1.867

Valinomycin0.5-10 uM Valinomycinrespiration

0.663

ZnSO42 mM ZnSO4respiration

0.384

menadione6-10 ug/mL Menadionerespiration

0.403

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.237

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.054

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.673

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.117

NRP_1Non-replicating persistence stage 1dosRassociated

0.136

Amp0.2mg/mL AmpicillincellWall

0.072

Cephalexin20-100 ug/mL CephalexincellWall

-0.213

Cerulenin0.32-5 ug/mL CerulenincellWall

0.656

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.217

EMB10-20 ug/mL EthambutolcellWall

0.521

Eta12-40 ug/mL EthionamidecellWall

0.580

INH0.2-0.4 ug/mL IsoniazidcellWall

0.437

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.084

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.239

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.282

BZA0.12 mg/mL BenzamidearomaticAmides

-0.381

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.460

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.011

H2O24 mM hydrogen peroxideDNAdamaging

1.371

Levo10 ug/mL LevofloxacinDNAdamaging

0.132

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.753

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.985

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.344

UVUV-irradiationDNAdamaging

-1.275

ARP41-4 ug/mL Antitubercular compound ARP4?

0.221

Antimycin12.5-50 ug/mL Antimycin A?

-0.063

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.756

PA_110-50 ug/mL Antitubercular compound PA-1?

0.135

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.225

PA8240.2-2 ug/mL PA-824?

-0.934

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.474

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.302

Verapamil50 uM Verapamil?

-0.164

mercaptoethanol2 mM 2-Mercaptoethanol?

0.081

methoxatin10-20 ug/mL Methoxatin?