from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1126c/-

LFCtreatmentdescriptionclass of inhibitor

-3.005

Amikacinug/mL Amikacintranslation

-1.236

Cap5-10ug/mL Capreomycintranslation

-2.067

Rox10-50 ug/mL Roxithromycintranslation

-0.169

SM2-5 ug/mL Streptomycintranslation

-4.882

Tet5-10 ug/mL Tetracyclinetranslation

-1.886

Rif0.2-5ug/mL Rifampicintranscription

0.118

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.050

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.281

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.347

CPZ10-50 ug/mL Chlorpromazinerespiration

1.268

Clofazimine10-13 ug/mL Clofaziminerespiration

0.786

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.571

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.335

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.899

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.229

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.085

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.176

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.920

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.638

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.197

KCN5-20 ug/mL Potassium cyaniderespiration

1.044

NaN30.2-2 mM Sodium aziderespiration

0.500

Nigericin50 uM Nigericinrespiration

-0.513

TRC10-150 ug/mL Triclosanrespiration

0.784

TRZ10-25 ug/mL Thioridazinerespiration

-0.402

Valinomycin0.5-10 uM Valinomycinrespiration

0.638

ZnSO42 mM ZnSO4respiration

0.175

menadione6-10 ug/mL Menadionerespiration

0.062

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.038

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.542

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.257

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.429

NRP_1Non-replicating persistence stage 1dosRassociated

0.448

Amp0.2mg/mL AmpicillincellWall

0.275

Cephalexin20-100 ug/mL CephalexincellWall

0.117

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.344

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.479

EMB10-20 ug/mL EthambutolcellWall

0.066

Eta12-40 ug/mL EthionamidecellWall

-0.361

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.164

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.104

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.191

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.704

BZA0.12 mg/mL BenzamidearomaticAmides

-0.704

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.307

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.221

H2O24 mM hydrogen peroxideDNAdamaging

-1.258

Levo10 ug/mL LevofloxacinDNAdamaging

-0.256

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.752

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.490

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.277

UVUV-irradiationDNAdamaging

-0.119

ARP41-4 ug/mL Antitubercular compound ARP4?

0.090

Antimycin12.5-50 ug/mL Antimycin A?

0.013

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.443

PA_110-50 ug/mL Antitubercular compound PA-1?

0.329

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.669

PA8240.2-2 ug/mL PA-824?

1.432

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.564

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.084

Verapamil50 uM Verapamil?

0.144

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.166

methoxatin10-20 ug/mL Methoxatin?