from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1106c/-

LFCtreatmentdescriptionclass of inhibitor

-0.543

Amikacinug/mL Amikacintranslation

0.906

Cap5-10ug/mL Capreomycintranslation

-0.028

Rox10-50 ug/mL Roxithromycintranslation

-0.218

SM2-5 ug/mL Streptomycintranslation

-1.301

Tet5-10 ug/mL Tetracyclinetranslation

-1.921

Rif0.2-5ug/mL Rifampicintranscription

-0.963

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.030

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.736

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.891

CPZ10-50 ug/mL Chlorpromazinerespiration

2.362

Clofazimine10-13 ug/mL Clofaziminerespiration

1.820

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.147

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.663

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.448

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.440

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.643

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.678

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.036

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.003

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.618

KCN5-20 ug/mL Potassium cyaniderespiration

-0.686

NaN30.2-2 mM Sodium aziderespiration

-0.778

Nigericin50 uM Nigericinrespiration

-0.402

TRC10-150 ug/mL Triclosanrespiration

0.402

TRZ10-25 ug/mL Thioridazinerespiration

-0.621

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.294

menadione6-10 ug/mL Menadionerespiration

0.401

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.246

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.599

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.785

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.338

NRP_1Non-replicating persistence stage 1dosRassociated

-0.190

Amp0.2mg/mL AmpicillincellWall

0.114

Cephalexin20-100 ug/mL CephalexincellWall

0.399

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.579

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.472

EMB10-20 ug/mL EthambutolcellWall

0.301

Eta12-40 ug/mL EthionamidecellWall

-0.037

INH0.2-0.4 ug/mL IsoniazidcellWall

0.217

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.677

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.013

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.763

BZA0.12 mg/mL BenzamidearomaticAmides

-0.504

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.120

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.049

H2O24 mM hydrogen peroxideDNAdamaging

0.635

Levo10 ug/mL LevofloxacinDNAdamaging

-0.200

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.154

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.201

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.059

UVUV-irradiationDNAdamaging

-0.072

ARP41-4 ug/mL Antitubercular compound ARP4?

0.510

Antimycin12.5-50 ug/mL Antimycin A?

-0.336

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.433

PA_110-50 ug/mL Antitubercular compound PA-1?

0.398

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.210

PA8240.2-2 ug/mL PA-824?

-0.056

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.519

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.815

Verapamil50 uM Verapamil?

-0.311

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.811

methoxatin10-20 ug/mL Methoxatin?