from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1103c/mazE3

LFCtreatmentdescriptionclass of inhibitor

2.267

Amikacinug/mL Amikacintranslation

2.100

Cap5-10ug/mL Capreomycintranslation

2.886

Rox10-50 ug/mL Roxithromycintranslation

1.514

SM2-5 ug/mL Streptomycintranslation

3.051

Tet5-10 ug/mL Tetracyclinetranslation

-1.510

Rif0.2-5ug/mL Rifampicintranscription

-0.202

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.171

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.734

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.328

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.818

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.673

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.861

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.478

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.199

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.464

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.383

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.463

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.030

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.571

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.245

KCN5-20 ug/mL Potassium cyaniderespiration

-0.227

NaN30.2-2 mM Sodium aziderespiration

0.179

Nigericin50 uM Nigericinrespiration

0.015

TRC10-150 ug/mL Triclosanrespiration

0.244

TRZ10-25 ug/mL Thioridazinerespiration

1.513

Valinomycin0.5-10 uM Valinomycinrespiration

-0.601

ZnSO42 mM ZnSO4respiration

0.831

menadione6-10 ug/mL Menadionerespiration

-0.235

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.080

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.070

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.009

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.114

NRP_1Non-replicating persistence stage 1dosRassociated

0.113

Amp0.2mg/mL AmpicillincellWall

0.275

Cephalexin20-100 ug/mL CephalexincellWall

0.678

Cerulenin0.32-5 ug/mL CerulenincellWall

0.427

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.316

EMB10-20 ug/mL EthambutolcellWall

1.213

Eta12-40 ug/mL EthionamidecellWall

1.035

INH0.2-0.4 ug/mL IsoniazidcellWall

0.392

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.113

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.033

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.281

BZA0.12 mg/mL BenzamidearomaticAmides

-0.409

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.089

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.213

H2O24 mM hydrogen peroxideDNAdamaging

-0.037

Levo10 ug/mL LevofloxacinDNAdamaging

-0.436

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.837

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.164

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.085

UVUV-irradiationDNAdamaging

0.503

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.291

Antimycin12.5-50 ug/mL Antimycin A?

-0.362

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.087

PA_110-50 ug/mL Antitubercular compound PA-1?

0.434

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.331

PA8240.2-2 ug/mL PA-824?

0.967

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.265

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.781

Verapamil50 uM Verapamil?

-0.182

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.453

methoxatin10-20 ug/mL Methoxatin?