from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1102c/mazF3

LFCtreatmentdescriptionclass of inhibitor

-0.372

Amikacinug/mL Amikacintranslation

1.716

Cap5-10ug/mL Capreomycintranslation

3.129

Rox10-50 ug/mL Roxithromycintranslation

1.231

SM2-5 ug/mL Streptomycintranslation

0.617

Tet5-10 ug/mL Tetracyclinetranslation

-1.316

Rif0.2-5ug/mL Rifampicintranscription

-0.326

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.008

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.295

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.105

CPZ10-50 ug/mL Chlorpromazinerespiration

0.744

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.132

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.703

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.445

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.689

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.234

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.247

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.381

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.784

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.802

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.416

KCN5-20 ug/mL Potassium cyaniderespiration

-0.082

NaN30.2-2 mM Sodium aziderespiration

1.656

Nigericin50 uM Nigericinrespiration

0.049

TRC10-150 ug/mL Triclosanrespiration

0.353

TRZ10-25 ug/mL Thioridazinerespiration

1.847

Valinomycin0.5-10 uM Valinomycinrespiration

0.340

ZnSO42 mM ZnSO4respiration

0.867

menadione6-10 ug/mL Menadionerespiration

-0.396

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.308

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.251

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.180

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.280

NRP_1Non-replicating persistence stage 1dosRassociated

0.289

Amp0.2mg/mL AmpicillincellWall

-0.183

Cephalexin20-100 ug/mL CephalexincellWall

0.661

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.013

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.158

EMB10-20 ug/mL EthambutolcellWall

-0.448

Eta12-40 ug/mL EthionamidecellWall

-0.869

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.457

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.851

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.138

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.495

BZA0.12 mg/mL BenzamidearomaticAmides

-0.359

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.812

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.392

H2O24 mM hydrogen peroxideDNAdamaging

-0.777

Levo10 ug/mL LevofloxacinDNAdamaging

0.098

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.116

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.884

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.266

UVUV-irradiationDNAdamaging

1.342

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.962

Antimycin12.5-50 ug/mL Antimycin A?

-0.010

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.012

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.012

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.600

PA8240.2-2 ug/mL PA-824?

1.092

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.347

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.105

Verapamil50 uM Verapamil?

-0.362

mercaptoethanol2 mM 2-Mercaptoethanol?

0.121

methoxatin10-20 ug/mL Methoxatin?