from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1095/phoH2

LFCtreatmentdescriptionclass of inhibitor

0.165

Amikacinug/mL Amikacintranslation

-0.959

Cap5-10ug/mL Capreomycintranslation

-1.143

Rox10-50 ug/mL Roxithromycintranslation

-0.026

SM2-5 ug/mL Streptomycintranslation

0.291

Tet5-10 ug/mL Tetracyclinetranslation

0.848

Rif0.2-5ug/mL Rifampicintranscription

0.142

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.153

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.803

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.396

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.049

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.027

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.266

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.620

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.296

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.041

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.456

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.484

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.287

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.733

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.833

KCN5-20 ug/mL Potassium cyaniderespiration

-0.261

NaN30.2-2 mM Sodium aziderespiration

-1.089

Nigericin50 uM Nigericinrespiration

0.301

TRC10-150 ug/mL Triclosanrespiration

0.982

TRZ10-25 ug/mL Thioridazinerespiration

0.032

Valinomycin0.5-10 uM Valinomycinrespiration

-1.450

ZnSO42 mM ZnSO4respiration

0.164

menadione6-10 ug/mL Menadionerespiration

-0.355

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.088

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-1.005

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.860

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.110

NRP_1Non-replicating persistence stage 1dosRassociated

-0.142

Amp0.2mg/mL AmpicillincellWall

0.537

Cephalexin20-100 ug/mL CephalexincellWall

-0.474

Cerulenin0.32-5 ug/mL CerulenincellWall

0.053

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.380

EMB10-20 ug/mL EthambutolcellWall

0.205

Eta12-40 ug/mL EthionamidecellWall

-0.115

INH0.2-0.4 ug/mL IsoniazidcellWall

0.144

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.563

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.341

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.424

BZA0.12 mg/mL BenzamidearomaticAmides

-0.210

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.148

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.185

H2O24 mM hydrogen peroxideDNAdamaging

-0.376

Levo10 ug/mL LevofloxacinDNAdamaging

-0.487

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.517

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.457

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.328

UVUV-irradiationDNAdamaging

0.690

ARP41-4 ug/mL Antitubercular compound ARP4?

-1.178

Antimycin12.5-50 ug/mL Antimycin A?

-0.262

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.820

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.725

PA_2110-50 ug/mL Antitubercular compound PA-21?

2.625

PA8240.2-2 ug/mL PA-824?

1.180

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.780

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.744

Verapamil50 uM Verapamil?

-0.285

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.032

methoxatin10-20 ug/mL Methoxatin?