from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1074c/fadA3

LFCtreatmentdescriptionclass of inhibitor

-0.940

Amikacinug/mL Amikacintranslation

-1.583

Cap5-10ug/mL Capreomycintranslation

-1.202

Rox10-50 ug/mL Roxithromycintranslation

-0.372

SM2-5 ug/mL Streptomycintranslation

-0.907

Tet5-10 ug/mL Tetracyclinetranslation

-0.037

Rif0.2-5ug/mL Rifampicintranscription

-0.652

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.342

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.026

CPZ10-50 ug/mL Chlorpromazinerespiration

3.099

Clofazimine10-13 ug/mL Clofaziminerespiration

0.264

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.493

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.549

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.122

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.977

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.697

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.470

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.713

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.786

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.206

Nigericin50 uM Nigericinrespiration

0.131

TRC10-150 ug/mL Triclosanrespiration

1.878

TRZ10-25 ug/mL Thioridazinerespiration

-0.575

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.064

menadione6-10 ug/mL Menadionerespiration

-0.245

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.158

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.464

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.485

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.299

NRP_1Non-replicating persistence stage 1dosRassociated

0.120

Amp0.2mg/mL AmpicillincellWall

1.343

Cephalexin20-100 ug/mL CephalexincellWall

-0.475

Cerulenin0.32-5 ug/mL CerulenincellWall

0.055

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.140

EMB10-20 ug/mL EthambutolcellWall

0.561

Eta12-40 ug/mL EthionamidecellWall

0.298

INH0.2-0.4 ug/mL IsoniazidcellWall

0.224

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.370

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.594

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.578

BZA0.12 mg/mL BenzamidearomaticAmides

-0.296

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.171

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.566

H2O24 mM hydrogen peroxideDNAdamaging

-0.743

Levo10 ug/mL LevofloxacinDNAdamaging

-0.307

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.573

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.405

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.923

UVUV-irradiationDNAdamaging

1.193

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.185

Antimycin12.5-50 ug/mL Antimycin A?

0.085

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.129

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.195

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.368

PA8240.2-2 ug/mL PA-824?

1.116

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.384

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.019

Verapamil50 uM Verapamil?

-0.587

mercaptoethanol2 mM 2-Mercaptoethanol?

1.052

methoxatin10-20 ug/mL Methoxatin?