from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1058/fadD14

LFCtreatmentdescriptionclass of inhibitor

-0.517

Amikacinug/mL Amikacintranslation

-1.729

Cap5-10ug/mL Capreomycintranslation

-0.489

Rox10-50 ug/mL Roxithromycintranslation

-0.162

SM2-5 ug/mL Streptomycintranslation

-1.145

Tet5-10 ug/mL Tetracyclinetranslation

1.133

Rif0.2-5ug/mL Rifampicintranscription

-0.402

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.671

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.086

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.029

CPZ10-50 ug/mL Chlorpromazinerespiration

0.292

Clofazimine10-13 ug/mL Clofaziminerespiration

0.655

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.364

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.371

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.517

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.103

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.096

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.021

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.068

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.094

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.177

KCN5-20 ug/mL Potassium cyaniderespiration

0.791

NaN30.2-2 mM Sodium aziderespiration

-0.341

Nigericin50 uM Nigericinrespiration

-0.326

TRC10-150 ug/mL Triclosanrespiration

0.734

TRZ10-25 ug/mL Thioridazinerespiration

-1.789

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.429

menadione6-10 ug/mL Menadionerespiration

-0.128

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.624

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.064

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.703

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.879

NRP_1Non-replicating persistence stage 1dosRassociated

1.075

Amp0.2mg/mL AmpicillincellWall

-0.360

Cephalexin20-100 ug/mL CephalexincellWall

-0.295

Cerulenin0.32-5 ug/mL CerulenincellWall

0.479

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.652

EMB10-20 ug/mL EthambutolcellWall

-0.844

Eta12-40 ug/mL EthionamidecellWall

-0.957

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.790

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.363

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.319

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.555

BZA0.12 mg/mL BenzamidearomaticAmides

0.025

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.351

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.339

H2O24 mM hydrogen peroxideDNAdamaging

-0.503

Levo10 ug/mL LevofloxacinDNAdamaging

0.283

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.938

Novobiocin10 ug/mL NovobiocinDNAdamaging

-1.037

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.098

UVUV-irradiationDNAdamaging

-1.112

ARP41-4 ug/mL Antitubercular compound ARP4?

0.033

Antimycin12.5-50 ug/mL Antimycin A?

-0.292

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.204

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.246

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.210

PA8240.2-2 ug/mL PA-824?

-1.228

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.725

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.404

Verapamil50 uM Verapamil?

-0.066

mercaptoethanol2 mM 2-Mercaptoethanol?

0.155

methoxatin10-20 ug/mL Methoxatin?