from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv1027c/kdpE

LFCtreatmentdescriptionclass of inhibitor

0.108

Amikacinug/mL Amikacintranslation

0.136

Cap5-10ug/mL Capreomycintranslation

-0.086

Rox10-50 ug/mL Roxithromycintranslation

-0.243

SM2-5 ug/mL Streptomycintranslation

0.318

Tet5-10 ug/mL Tetracyclinetranslation

0.363

Rif0.2-5ug/mL Rifampicintranscription

1.289

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.895

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.630

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.985

CPZ10-50 ug/mL Chlorpromazinerespiration

1.306

Clofazimine10-13 ug/mL Clofaziminerespiration

0.187

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.129

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.593

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.374

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.487

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.970

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.552

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.845

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.668

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.008

KCN5-20 ug/mL Potassium cyaniderespiration

0.678

NaN30.2-2 mM Sodium aziderespiration

-0.531

Nigericin50 uM Nigericinrespiration

0.315

TRC10-150 ug/mL Triclosanrespiration

1.887

TRZ10-25 ug/mL Thioridazinerespiration

0.892

Valinomycin0.5-10 uM Valinomycinrespiration

-0.119

ZnSO42 mM ZnSO4respiration

0.733

menadione6-10 ug/mL Menadionerespiration

0.433

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.256

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.075

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.091

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.986

NRP_1Non-replicating persistence stage 1dosRassociated

-0.539

Amp0.2mg/mL AmpicillincellWall

-0.470

Cephalexin20-100 ug/mL CephalexincellWall

-0.110

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.892

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.456

EMB10-20 ug/mL EthambutolcellWall

0.031

Eta12-40 ug/mL EthionamidecellWall

0.052

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.288

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.349

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.080

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.707

BZA0.12 mg/mL BenzamidearomaticAmides

-0.403

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.783

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.909

H2O24 mM hydrogen peroxideDNAdamaging

-0.318

Levo10 ug/mL LevofloxacinDNAdamaging

-1.544

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.199

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.524

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.672

UVUV-irradiationDNAdamaging

0.899

ARP41-4 ug/mL Antitubercular compound ARP4?

0.167

Antimycin12.5-50 ug/mL Antimycin A?

0.002

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.062

PA_110-50 ug/mL Antitubercular compound PA-1?

0.163

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.399

PA8240.2-2 ug/mL PA-824?

0.024

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.197

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.029

Verapamil50 uM Verapamil?

0.085

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.031

methoxatin10-20 ug/mL Methoxatin?