from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0972c/fadE12

LFCtreatmentdescriptionclass of inhibitor

-0.519

Amikacinug/mL Amikacintranslation

0.313

Cap5-10ug/mL Capreomycintranslation

-0.167

Rox10-50 ug/mL Roxithromycintranslation

0.000

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.352

Rif0.2-5ug/mL Rifampicintranscription

-0.163

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.938

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.577

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.348

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.755

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.238

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.478

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.727

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.266

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.427

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.179

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.264

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.011

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.684

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.761

KCN5-20 ug/mL Potassium cyaniderespiration

-0.533

NaN30.2-2 mM Sodium aziderespiration

-0.349

Nigericin50 uM Nigericinrespiration

0.547

TRC10-150 ug/mL Triclosanrespiration

0.608

TRZ10-25 ug/mL Thioridazinerespiration

-0.611

Valinomycin0.5-10 uM Valinomycinrespiration

0.529

ZnSO42 mM ZnSO4respiration

-0.568

menadione6-10 ug/mL Menadionerespiration

-0.440

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.375

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.354

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.267

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.588

NRP_1Non-replicating persistence stage 1dosRassociated

-0.678

Amp0.2mg/mL AmpicillincellWall

0.063

Cephalexin20-100 ug/mL CephalexincellWall

-0.298

Cerulenin0.32-5 ug/mL CerulenincellWall

0.000

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.301

EMB10-20 ug/mL EthambutolcellWall

0.910

Eta12-40 ug/mL EthionamidecellWall

0.035

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.047

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.416

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.813

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

1.752

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.631

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.012

H2O24 mM hydrogen peroxideDNAdamaging

-0.361

Levo10 ug/mL LevofloxacinDNAdamaging

0.946

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.486

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.697

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.411

UVUV-irradiationDNAdamaging

-0.378

ARP41-4 ug/mL Antitubercular compound ARP4?

0.274

Antimycin12.5-50 ug/mL Antimycin A?

-0.329

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.887

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.990

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.640

PA8240.2-2 ug/mL PA-824?

2.398

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.803

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.352

Verapamil50 uM Verapamil?

-0.092

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.457

methoxatin10-20 ug/mL Methoxatin?