from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0944/-

LFCtreatmentdescriptionclass of inhibitor

0.343

Amikacinug/mL Amikacintranslation

-0.352

Cap5-10ug/mL Capreomycintranslation

0.049

Rox10-50 ug/mL Roxithromycintranslation

-0.627

SM2-5 ug/mL Streptomycintranslation

-0.239

Tet5-10 ug/mL Tetracyclinetranslation

0.883

Rif0.2-5ug/mL Rifampicintranscription

0.462

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.173

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.384

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.301

CPZ10-50 ug/mL Chlorpromazinerespiration

0.725

Clofazimine10-13 ug/mL Clofaziminerespiration

0.357

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.966

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.502

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.750

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.353

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.107

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.478

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.931

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.128

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.124

KCN5-20 ug/mL Potassium cyaniderespiration

1.861

NaN30.2-2 mM Sodium aziderespiration

-0.023

Nigericin50 uM Nigericinrespiration

0.220

TRC10-150 ug/mL Triclosanrespiration

-0.763

TRZ10-25 ug/mL Thioridazinerespiration

0.517

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.484

menadione6-10 ug/mL Menadionerespiration

-0.023

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.288

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.399

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.245

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.272

NRP_1Non-replicating persistence stage 1dosRassociated

-0.674

Amp0.2mg/mL AmpicillincellWall

-0.294

Cephalexin20-100 ug/mL CephalexincellWall

-0.056

Cerulenin0.32-5 ug/mL CerulenincellWall

0.329

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.206

EMB10-20 ug/mL EthambutolcellWall

-0.772

Eta12-40 ug/mL EthionamidecellWall

-1.267

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.564

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.091

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.343

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.323

BZA0.12 mg/mL BenzamidearomaticAmides

0.265

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.296

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.998

H2O24 mM hydrogen peroxideDNAdamaging

0.257

Levo10 ug/mL LevofloxacinDNAdamaging

0.449

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.768

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.516

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.545

UVUV-irradiationDNAdamaging

-0.224

ARP41-4 ug/mL Antitubercular compound ARP4?

0.028

Antimycin12.5-50 ug/mL Antimycin A?

-0.774

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.395

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.482

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.541

PA8240.2-2 ug/mL PA-824?

-0.098

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.204

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.866

Verapamil50 uM Verapamil?

-0.996

mercaptoethanol2 mM 2-Mercaptoethanol?

0.151

methoxatin10-20 ug/mL Methoxatin?