from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0943c/-

LFCtreatmentdescriptionclass of inhibitor

-0.551

Amikacinug/mL Amikacintranslation

-0.727

Cap5-10ug/mL Capreomycintranslation

0.706

Rox10-50 ug/mL Roxithromycintranslation

0.802

SM2-5 ug/mL Streptomycintranslation

2.636

Tet5-10 ug/mL Tetracyclinetranslation

-0.336

Rif0.2-5ug/mL Rifampicintranscription

0.406

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.603

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.721

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.185

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.540

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.211

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.184

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.000

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.000

Nigericin50 uM Nigericinrespiration

-0.368

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-1.069

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.000

menadione6-10 ug/mL Menadionerespiration

0.127

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.316

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.031

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.000

NRP_1Non-replicating persistence stage 1dosRassociated

-0.569

Amp0.2mg/mL AmpicillincellWall

-0.074

Cephalexin20-100 ug/mL CephalexincellWall

0.461

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.323

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.580

EMB10-20 ug/mL EthambutolcellWall

-0.356

Eta12-40 ug/mL EthionamidecellWall

-0.265

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.395

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.749

BZA0.12 mg/mL BenzamidearomaticAmides

0.395

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.715

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.198

H2O24 mM hydrogen peroxideDNAdamaging

0.105

Levo10 ug/mL LevofloxacinDNAdamaging

-0.174

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.186

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.100

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.025

Antimycin12.5-50 ug/mL Antimycin A?

1.037

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.484

PA_110-50 ug/mL Antitubercular compound PA-1?

1.150

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.283

PA8240.2-2 ug/mL PA-824?

-0.133

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.099

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-0.109

mercaptoethanol2 mM 2-Mercaptoethanol?

0.000

methoxatin10-20 ug/mL Methoxatin?