from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0941c/-

LFCtreatmentdescriptionclass of inhibitor

-0.133

Amikacinug/mL Amikacintranslation

0.236

Cap5-10ug/mL Capreomycintranslation

1.201

Rox10-50 ug/mL Roxithromycintranslation

-0.186

SM2-5 ug/mL Streptomycintranslation

0.022

Tet5-10 ug/mL Tetracyclinetranslation

1.087

Rif0.2-5ug/mL Rifampicintranscription

-0.409

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.182

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.673

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.607

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.546

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.700

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.112

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.030

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.073

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.184

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.708

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.435

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.560

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.340

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.324

KCN5-20 ug/mL Potassium cyaniderespiration

-0.839

NaN30.2-2 mM Sodium aziderespiration

0.885

Nigericin50 uM Nigericinrespiration

0.737

TRC10-150 ug/mL Triclosanrespiration

1.029

TRZ10-25 ug/mL Thioridazinerespiration

0.682

Valinomycin0.5-10 uM Valinomycinrespiration

-0.010

ZnSO42 mM ZnSO4respiration

-1.871

menadione6-10 ug/mL Menadionerespiration

-0.141

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.476

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.840

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.873

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.187

NRP_1Non-replicating persistence stage 1dosRassociated

-0.367

Amp0.2mg/mL AmpicillincellWall

-0.438

Cephalexin20-100 ug/mL CephalexincellWall

-0.512

Cerulenin0.32-5 ug/mL CerulenincellWall

0.115

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.085

EMB10-20 ug/mL EthambutolcellWall

-0.695

Eta12-40 ug/mL EthionamidecellWall

-0.952

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.169

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.388

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.781

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.393

BZA0.12 mg/mL BenzamidearomaticAmides

0.776

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.406

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.959

H2O24 mM hydrogen peroxideDNAdamaging

-0.629

Levo10 ug/mL LevofloxacinDNAdamaging

0.401

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.082

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.214

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.027

UVUV-irradiationDNAdamaging

-0.715

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.136

Antimycin12.5-50 ug/mL Antimycin A?

-1.746

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.338

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.039

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.309

PA8240.2-2 ug/mL PA-824?

0.489

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.079

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.893

Verapamil50 uM Verapamil?

-0.602

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.763

methoxatin10-20 ug/mL Methoxatin?