from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0930/pstA1

LFCtreatmentdescriptionclass of inhibitor

-0.740

Amikacinug/mL Amikacintranslation

-0.477

Cap5-10ug/mL Capreomycintranslation

0.277

Rox10-50 ug/mL Roxithromycintranslation

-0.052

SM2-5 ug/mL Streptomycintranslation

-3.126

Tet5-10 ug/mL Tetracyclinetranslation

0.032

Rif0.2-5ug/mL Rifampicintranscription

0.002

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.090

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.204

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.342

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.090

Clofazimine10-13 ug/mL Clofaziminerespiration

0.970

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.790

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.274

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.628

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.954

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.700

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.379

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.083

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.684

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.176

KCN5-20 ug/mL Potassium cyaniderespiration

0.949

NaN30.2-2 mM Sodium aziderespiration

0.432

Nigericin50 uM Nigericinrespiration

-0.840

TRC10-150 ug/mL Triclosanrespiration

-0.809

TRZ10-25 ug/mL Thioridazinerespiration

0.086

Valinomycin0.5-10 uM Valinomycinrespiration

3.404

ZnSO42 mM ZnSO4respiration

-0.571

menadione6-10 ug/mL Menadionerespiration

-0.388

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.291

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.656

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.907

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.004

NRP_1Non-replicating persistence stage 1dosRassociated

-0.239

Amp0.2mg/mL AmpicillincellWall

0.664

Cephalexin20-100 ug/mL CephalexincellWall

-0.222

Cerulenin0.32-5 ug/mL CerulenincellWall

0.028

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.059

EMB10-20 ug/mL EthambutolcellWall

-0.481

Eta12-40 ug/mL EthionamidecellWall

-0.194

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.377

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.261

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.512

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.056

BZA0.12 mg/mL BenzamidearomaticAmides

-0.814

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.171

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.030

H2O24 mM hydrogen peroxideDNAdamaging

-0.367

Levo10 ug/mL LevofloxacinDNAdamaging

-0.057

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.107

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.767

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.198

UVUV-irradiationDNAdamaging

-0.436

ARP41-4 ug/mL Antitubercular compound ARP4?

0.195

Antimycin12.5-50 ug/mL Antimycin A?

0.578

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.572

PA_110-50 ug/mL Antitubercular compound PA-1?

0.570

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.929

PA8240.2-2 ug/mL PA-824?

0.890

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.619

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.665

Verapamil50 uM Verapamil?

0.797

mercaptoethanol2 mM 2-Mercaptoethanol?

0.612

methoxatin10-20 ug/mL Methoxatin?