from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0923c/-

LFCtreatmentdescriptionclass of inhibitor

-0.169

Amikacinug/mL Amikacintranslation

-1.260

Cap5-10ug/mL Capreomycintranslation

-0.922

Rox10-50 ug/mL Roxithromycintranslation

0.794

SM2-5 ug/mL Streptomycintranslation

-1.069

Tet5-10 ug/mL Tetracyclinetranslation

0.667

Rif0.2-5ug/mL Rifampicintranscription

0.059

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.784

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.659

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.310

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-4.390

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.639

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.422

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.277

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.923

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.966

Nigericin50 uM Nigericinrespiration

0.090

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.281

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.131

menadione6-10 ug/mL Menadionerespiration

-0.786

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.249

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-1.017

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

2.793

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.831

NRP_1Non-replicating persistence stage 1dosRassociated

0.148

Amp0.2mg/mL AmpicillincellWall

-0.278

Cephalexin20-100 ug/mL CephalexincellWall

-0.157

Cerulenin0.32-5 ug/mL CerulenincellWall

0.305

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.412

EMB10-20 ug/mL EthambutolcellWall

-0.118

Eta12-40 ug/mL EthionamidecellWall

-0.218

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.245

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-2.026

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.296

BZA0.12 mg/mL BenzamidearomaticAmides

0.473

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.935

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.743

H2O24 mM hydrogen peroxideDNAdamaging

-0.160

Levo10 ug/mL LevofloxacinDNAdamaging

-0.022

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.340

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.316

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.220

UVUV-irradiationDNAdamaging

-1.682

ARP41-4 ug/mL Antitubercular compound ARP4?

0.148

Antimycin12.5-50 ug/mL Antimycin A?

0.832

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.640

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.415

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.149

PA8240.2-2 ug/mL PA-824?

-1.309

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.262

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.364

Verapamil50 uM Verapamil?

-2.169

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.892

methoxatin10-20 ug/mL Methoxatin?