from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0922/-

LFCtreatmentdescriptionclass of inhibitor

-0.496

Amikacinug/mL Amikacintranslation

0.201

Cap5-10ug/mL Capreomycintranslation

0.346

Rox10-50 ug/mL Roxithromycintranslation

0.299

SM2-5 ug/mL Streptomycintranslation

-0.470

Tet5-10 ug/mL Tetracyclinetranslation

-0.241

Rif0.2-5ug/mL Rifampicintranscription

-0.714

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.733

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.850

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.876

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.571

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.312

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.655

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.235

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.481

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.843

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.502

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.021

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.053

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

2.667

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.453

KCN5-20 ug/mL Potassium cyaniderespiration

-0.588

NaN30.2-2 mM Sodium aziderespiration

0.161

Nigericin50 uM Nigericinrespiration

-0.574

TRC10-150 ug/mL Triclosanrespiration

-1.325

TRZ10-25 ug/mL Thioridazinerespiration

2.013

Valinomycin0.5-10 uM Valinomycinrespiration

-0.453

ZnSO42 mM ZnSO4respiration

2.512

menadione6-10 ug/mL Menadionerespiration

-0.403

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.498

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.275

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.640

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.284

NRP_1Non-replicating persistence stage 1dosRassociated

-0.660

Amp0.2mg/mL AmpicillincellWall

-0.380

Cephalexin20-100 ug/mL CephalexincellWall

0.427

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.176

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.078

EMB10-20 ug/mL EthambutolcellWall

-0.806

Eta12-40 ug/mL EthionamidecellWall

-0.694

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.697

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.144

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.102

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.142

BZA0.12 mg/mL BenzamidearomaticAmides

0.108

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.377

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.030

H2O24 mM hydrogen peroxideDNAdamaging

1.901

Levo10 ug/mL LevofloxacinDNAdamaging

0.610

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.274

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.878

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.892

UVUV-irradiationDNAdamaging

0.068

ARP41-4 ug/mL Antitubercular compound ARP4?

0.091

Antimycin12.5-50 ug/mL Antimycin A?

-0.008

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.069

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.212

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.189

PA8240.2-2 ug/mL PA-824?

-0.114

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.107

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.578

Verapamil50 uM Verapamil?

-0.301

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.207

methoxatin10-20 ug/mL Methoxatin?