from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0914c/-

LFCtreatmentdescriptionclass of inhibitor

-1.138

Amikacinug/mL Amikacintranslation

-0.205

Cap5-10ug/mL Capreomycintranslation

-0.852

Rox10-50 ug/mL Roxithromycintranslation

-0.578

SM2-5 ug/mL Streptomycintranslation

-2.168

Tet5-10 ug/mL Tetracyclinetranslation

-0.163

Rif0.2-5ug/mL Rifampicintranscription

-0.965

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.513

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.064

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.040

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

5.157

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.463

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.204

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.500

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.000

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.267

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.029

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.035

Nigericin50 uM Nigericinrespiration

0.113

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.488

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.231

menadione6-10 ug/mL Menadionerespiration

-0.574

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.618

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.715

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.000

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.000

NRP_1Non-replicating persistence stage 1dosRassociated

0.136

Amp0.2mg/mL AmpicillincellWall

-0.139

Cephalexin20-100 ug/mL CephalexincellWall

-0.297

Cerulenin0.32-5 ug/mL CerulenincellWall

0.352

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.123

EMB10-20 ug/mL EthambutolcellWall

-0.355

Eta12-40 ug/mL EthionamidecellWall

-1.070

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.080

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.518

BZA0.12 mg/mL BenzamidearomaticAmides

0.144

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.114

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.357

H2O24 mM hydrogen peroxideDNAdamaging

-0.401

Levo10 ug/mL LevofloxacinDNAdamaging

0.563

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.445

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.930

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.113

Antimycin12.5-50 ug/mL Antimycin A?

-0.395

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.597

PA_110-50 ug/mL Antitubercular compound PA-1?

0.213

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.513

PA8240.2-2 ug/mL PA-824?

-0.629

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.159

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-0.360

mercaptoethanol2 mM 2-Mercaptoethanol?

0.000

methoxatin10-20 ug/mL Methoxatin?