from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0910/-

LFCtreatmentdescriptionclass of inhibitor

-2.296

Amikacinug/mL Amikacintranslation

-0.100

Cap5-10ug/mL Capreomycintranslation

-0.616

Rox10-50 ug/mL Roxithromycintranslation

-0.107

SM2-5 ug/mL Streptomycintranslation

-1.274

Tet5-10 ug/mL Tetracyclinetranslation

-1.265

Rif0.2-5ug/mL Rifampicintranscription

-0.003

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.005

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.322

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.667

CPZ10-50 ug/mL Chlorpromazinerespiration

0.823

Clofazimine10-13 ug/mL Clofaziminerespiration

1.035

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.931

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.821

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.708

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.642

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.065

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.195

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.561

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.012

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.746

KCN5-20 ug/mL Potassium cyaniderespiration

1.249

NaN30.2-2 mM Sodium aziderespiration

-0.170

Nigericin50 uM Nigericinrespiration

-1.118

TRC10-150 ug/mL Triclosanrespiration

-1.098

TRZ10-25 ug/mL Thioridazinerespiration

-0.700

Valinomycin0.5-10 uM Valinomycinrespiration

1.273

ZnSO42 mM ZnSO4respiration

0.108

menadione6-10 ug/mL Menadionerespiration

-0.092

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.583

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.244

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.907

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.510

NRP_1Non-replicating persistence stage 1dosRassociated

0.436

Amp0.2mg/mL AmpicillincellWall

0.171

Cephalexin20-100 ug/mL CephalexincellWall

0.238

Cerulenin0.32-5 ug/mL CerulenincellWall

0.176

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.042

EMB10-20 ug/mL EthambutolcellWall

0.312

Eta12-40 ug/mL EthionamidecellWall

0.633

INH0.2-0.4 ug/mL IsoniazidcellWall

0.337

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.436

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.609

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.436

BZA0.12 mg/mL BenzamidearomaticAmides

-0.202

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.255

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.471

H2O24 mM hydrogen peroxideDNAdamaging

-0.331

Levo10 ug/mL LevofloxacinDNAdamaging

0.759

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.110

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.152

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.569

UVUV-irradiationDNAdamaging

-0.783

ARP41-4 ug/mL Antitubercular compound ARP4?

0.192

Antimycin12.5-50 ug/mL Antimycin A?

0.841

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.201

PA_110-50 ug/mL Antitubercular compound PA-1?

0.460

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.893

PA8240.2-2 ug/mL PA-824?

0.629

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.523

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.694

Verapamil50 uM Verapamil?

0.144

mercaptoethanol2 mM 2-Mercaptoethanol?

0.579

methoxatin10-20 ug/mL Methoxatin?