from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0909/-

LFCtreatmentdescriptionclass of inhibitor

1.946

Amikacinug/mL Amikacintranslation

1.089

Cap5-10ug/mL Capreomycintranslation

1.126

Rox10-50 ug/mL Roxithromycintranslation

0.438

SM2-5 ug/mL Streptomycintranslation

1.992

Tet5-10 ug/mL Tetracyclinetranslation

-0.296

Rif0.2-5ug/mL Rifampicintranscription

0.160

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.249

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.505

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.887

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.530

Clofazimine10-13 ug/mL Clofaziminerespiration

0.269

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.189

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.855

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.256

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.075

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.524

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.436

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.289

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.067

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.633

KCN5-20 ug/mL Potassium cyaniderespiration

-0.346

NaN30.2-2 mM Sodium aziderespiration

-0.796

Nigericin50 uM Nigericinrespiration

-0.949

TRC10-150 ug/mL Triclosanrespiration

-0.784

TRZ10-25 ug/mL Thioridazinerespiration

-0.205

Valinomycin0.5-10 uM Valinomycinrespiration

0.718

ZnSO42 mM ZnSO4respiration

-0.839

menadione6-10 ug/mL Menadionerespiration

-0.533

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.665

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.074

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.869

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.074

NRP_1Non-replicating persistence stage 1dosRassociated

0.308

Amp0.2mg/mL AmpicillincellWall

0.107

Cephalexin20-100 ug/mL CephalexincellWall

0.228

Cerulenin0.32-5 ug/mL CerulenincellWall

0.378

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.103

EMB10-20 ug/mL EthambutolcellWall

0.702

Eta12-40 ug/mL EthionamidecellWall

1.330

INH0.2-0.4 ug/mL IsoniazidcellWall

0.426

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.637

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.019

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.201

BZA0.12 mg/mL BenzamidearomaticAmides

0.008

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.155

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.554

H2O24 mM hydrogen peroxideDNAdamaging

0.406

Levo10 ug/mL LevofloxacinDNAdamaging

0.798

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.125

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.640

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.670

UVUV-irradiationDNAdamaging

-1.951

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.498

Antimycin12.5-50 ug/mL Antimycin A?

0.190

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.042

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.088

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.460

PA8240.2-2 ug/mL PA-824?

-0.656

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.119

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.297

Verapamil50 uM Verapamil?

-0.235

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.535

methoxatin10-20 ug/mL Methoxatin?