from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0907/-

LFCtreatmentdescriptionclass of inhibitor

-0.279

Amikacinug/mL Amikacintranslation

-1.601

Cap5-10ug/mL Capreomycintranslation

-1.581

Rox10-50 ug/mL Roxithromycintranslation

-0.395

SM2-5 ug/mL Streptomycintranslation

-0.877

Tet5-10 ug/mL Tetracyclinetranslation

1.256

Rif0.2-5ug/mL Rifampicintranscription

0.514

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.504

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.503

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.565

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.357

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.608

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.555

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.071

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.502

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.447

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

-0.089

NaN30.2-2 mM Sodium aziderespiration

-0.857

Nigericin50 uM Nigericinrespiration

0.330

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-1.476

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.304

menadione6-10 ug/mL Menadionerespiration

-0.171

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.162

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.395

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.218

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.226

NRP_1Non-replicating persistence stage 1dosRassociated

0.071

Amp0.2mg/mL AmpicillincellWall

-0.133

Cephalexin20-100 ug/mL CephalexincellWall

-0.527

Cerulenin0.32-5 ug/mL CerulenincellWall

1.032

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.323

EMB10-20 ug/mL EthambutolcellWall

-0.845

Eta12-40 ug/mL EthionamidecellWall

-1.013

INH0.2-0.4 ug/mL IsoniazidcellWall

0.247

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.689

BZA0.12 mg/mL BenzamidearomaticAmides

0.298

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.383

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.373

H2O24 mM hydrogen peroxideDNAdamaging

-0.352

Levo10 ug/mL LevofloxacinDNAdamaging

0.479

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.772

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.597

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.382

Antimycin12.5-50 ug/mL Antimycin A?

-0.912

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.232

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.145

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.290

PA8240.2-2 ug/mL PA-824?

0.108

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.261

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.986

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.806

methoxatin10-20 ug/mL Methoxatin?