from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0883c/-

LFCtreatmentdescriptionclass of inhibitor

1.487

Amikacinug/mL Amikacintranslation

1.125

Cap5-10ug/mL Capreomycintranslation

1.587

Rox10-50 ug/mL Roxithromycintranslation

0.326

SM2-5 ug/mL Streptomycintranslation

2.238

Tet5-10 ug/mL Tetracyclinetranslation

0.208

Rif0.2-5ug/mL Rifampicintranscription

0.170

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.380

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.848

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.844

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.256

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.371

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.722

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.134

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.769

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.760

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.381

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.818

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.075

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.303

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.604

KCN5-20 ug/mL Potassium cyaniderespiration

0.056

NaN30.2-2 mM Sodium aziderespiration

-0.651

Nigericin50 uM Nigericinrespiration

0.471

TRC10-150 ug/mL Triclosanrespiration

0.032

TRZ10-25 ug/mL Thioridazinerespiration

-1.405

Valinomycin0.5-10 uM Valinomycinrespiration

0.618

ZnSO42 mM ZnSO4respiration

-1.016

menadione6-10 ug/mL Menadionerespiration

-0.478

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.372

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.543

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.516

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.386

NRP_1Non-replicating persistence stage 1dosRassociated

0.652

Amp0.2mg/mL AmpicillincellWall

1.091

Cephalexin20-100 ug/mL CephalexincellWall

-0.132

Cerulenin0.32-5 ug/mL CerulenincellWall

0.154

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.285

EMB10-20 ug/mL EthambutolcellWall

0.856

Eta12-40 ug/mL EthionamidecellWall

0.668

INH0.2-0.4 ug/mL IsoniazidcellWall

0.146

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.837

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.534

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.150

BZA0.12 mg/mL BenzamidearomaticAmides

0.088

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.170

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.951

H2O24 mM hydrogen peroxideDNAdamaging

-0.013

Levo10 ug/mL LevofloxacinDNAdamaging

-0.444

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.371

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.049

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.074

UVUV-irradiationDNAdamaging

-0.093

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.482

Antimycin12.5-50 ug/mL Antimycin A?

0.784

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.139

PA_110-50 ug/mL Antitubercular compound PA-1?

0.585

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.063

PA8240.2-2 ug/mL PA-824?

1.374

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.198

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.297

Verapamil50 uM Verapamil?

0.243

mercaptoethanol2 mM 2-Mercaptoethanol?

0.411

methoxatin10-20 ug/mL Methoxatin?