from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0882/-

LFCtreatmentdescriptionclass of inhibitor

-0.791

Amikacinug/mL Amikacintranslation

-0.980

Cap5-10ug/mL Capreomycintranslation

-1.169

Rox10-50 ug/mL Roxithromycintranslation

-0.449

SM2-5 ug/mL Streptomycintranslation

-0.936

Tet5-10 ug/mL Tetracyclinetranslation

0.930

Rif0.2-5ug/mL Rifampicintranscription

-0.357

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.821

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.549

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.544

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.775

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.686

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.077

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.060

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.297

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.829

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.501

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.941

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.737

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.077

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.204

KCN5-20 ug/mL Potassium cyaniderespiration

-0.473

NaN30.2-2 mM Sodium aziderespiration

0.228

Nigericin50 uM Nigericinrespiration

0.612

TRC10-150 ug/mL Triclosanrespiration

-0.542

TRZ10-25 ug/mL Thioridazinerespiration

-0.584

Valinomycin0.5-10 uM Valinomycinrespiration

-1.074

ZnSO42 mM ZnSO4respiration

0.910

menadione6-10 ug/mL Menadionerespiration

0.409

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.017

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.400

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.583

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.508

NRP_1Non-replicating persistence stage 1dosRassociated

0.120

Amp0.2mg/mL AmpicillincellWall

-0.071

Cephalexin20-100 ug/mL CephalexincellWall

-0.524

Cerulenin0.32-5 ug/mL CerulenincellWall

1.272

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.822

EMB10-20 ug/mL EthambutolcellWall

-0.593

Eta12-40 ug/mL EthionamidecellWall

-0.424

INH0.2-0.4 ug/mL IsoniazidcellWall

0.122

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.603

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.309

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.287

BZA0.12 mg/mL BenzamidearomaticAmides

-0.088

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.279

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.022

H2O24 mM hydrogen peroxideDNAdamaging

-0.745

Levo10 ug/mL LevofloxacinDNAdamaging

-0.474

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.134

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.315

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.582

UVUV-irradiationDNAdamaging

0.331

ARP41-4 ug/mL Antitubercular compound ARP4?

0.122

Antimycin12.5-50 ug/mL Antimycin A?

-0.205

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.676

PA_110-50 ug/mL Antitubercular compound PA-1?

0.752

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.271

PA8240.2-2 ug/mL PA-824?

0.223

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.229

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.191

Verapamil50 uM Verapamil?

0.214

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.266

methoxatin10-20 ug/mL Methoxatin?