from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0881/-

LFCtreatmentdescriptionclass of inhibitor

0.000

Amikacinug/mL Amikacintranslation

0.735

Cap5-10ug/mL Capreomycintranslation

0.000

Rox10-50 ug/mL Roxithromycintranslation

0.000

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.692

Rif0.2-5ug/mL Rifampicintranscription

0.850

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.120

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.590

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.614

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.145

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.407

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.641

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.534

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.996

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.393

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.067

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.532

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.785

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.338

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.598

KCN5-20 ug/mL Potassium cyaniderespiration

0.219

NaN30.2-2 mM Sodium aziderespiration

0.295

Nigericin50 uM Nigericinrespiration

-0.027

TRC10-150 ug/mL Triclosanrespiration

-0.586

TRZ10-25 ug/mL Thioridazinerespiration

0.081

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.833

menadione6-10 ug/mL Menadionerespiration

1.408

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

1.723

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.543

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.235

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.196

NRP_1Non-replicating persistence stage 1dosRassociated

0.000

Amp0.2mg/mL AmpicillincellWall

0.261

Cephalexin20-100 ug/mL CephalexincellWall

0.025

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.171

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.264

EMB10-20 ug/mL EthambutolcellWall

0.000

Eta12-40 ug/mL EthionamidecellWall

0.000

INH0.2-0.4 ug/mL IsoniazidcellWall

0.000

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.133

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.215

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.744

BZA0.12 mg/mL BenzamidearomaticAmides

-0.221

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.055

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.555

H2O24 mM hydrogen peroxideDNAdamaging

0.000

Levo10 ug/mL LevofloxacinDNAdamaging

0.569

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.776

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.000

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.351

UVUV-irradiationDNAdamaging

-0.753

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.398

Antimycin12.5-50 ug/mL Antimycin A?

0.229

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.275

PA_110-50 ug/mL Antitubercular compound PA-1?

0.855

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.073

PA8240.2-2 ug/mL PA-824?

-1.063

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.221

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.458

Verapamil50 uM Verapamil?

-0.311

mercaptoethanol2 mM 2-Mercaptoethanol?

0.285

methoxatin10-20 ug/mL Methoxatin?