from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0879c/-

LFCtreatmentdescriptionclass of inhibitor

-0.409

Amikacinug/mL Amikacintranslation

-1.459

Cap5-10ug/mL Capreomycintranslation

-1.321

Rox10-50 ug/mL Roxithromycintranslation

-0.078

SM2-5 ug/mL Streptomycintranslation

-0.771

Tet5-10 ug/mL Tetracyclinetranslation

0.095

Rif0.2-5ug/mL Rifampicintranscription

0.067

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.270

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.150

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.454

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.196

Clofazimine10-13 ug/mL Clofaziminerespiration

0.064

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.110

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.122

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.335

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.225

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.150

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.664

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.729

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.532

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.897

KCN5-20 ug/mL Potassium cyaniderespiration

0.017

NaN30.2-2 mM Sodium aziderespiration

0.718

Nigericin50 uM Nigericinrespiration

-0.175

TRC10-150 ug/mL Triclosanrespiration

-0.656

TRZ10-25 ug/mL Thioridazinerespiration

-0.909

Valinomycin0.5-10 uM Valinomycinrespiration

0.616

ZnSO42 mM ZnSO4respiration

0.376

menadione6-10 ug/mL Menadionerespiration

0.700

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.480

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.167

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.557

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.339

NRP_1Non-replicating persistence stage 1dosRassociated

0.435

Amp0.2mg/mL AmpicillincellWall

0.367

Cephalexin20-100 ug/mL CephalexincellWall

0.477

Cerulenin0.32-5 ug/mL CerulenincellWall

0.235

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

1.036

EMB10-20 ug/mL EthambutolcellWall

1.704

Eta12-40 ug/mL EthionamidecellWall

2.103

INH0.2-0.4 ug/mL IsoniazidcellWall

1.001

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.328

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.258

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.030

BZA0.12 mg/mL BenzamidearomaticAmides

-0.198

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.091

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.086

H2O24 mM hydrogen peroxideDNAdamaging

0.427

Levo10 ug/mL LevofloxacinDNAdamaging

0.264

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.772

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.846

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.430

UVUV-irradiationDNAdamaging

-0.942

ARP41-4 ug/mL Antitubercular compound ARP4?

0.488

Antimycin12.5-50 ug/mL Antimycin A?

0.264

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.780

PA_110-50 ug/mL Antitubercular compound PA-1?

0.984

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.743

PA8240.2-2 ug/mL PA-824?

-1.142

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.240

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.142

Verapamil50 uM Verapamil?

0.426

mercaptoethanol2 mM 2-Mercaptoethanol?

0.050

methoxatin10-20 ug/mL Methoxatin?