from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0862c/-

LFCtreatmentdescriptionclass of inhibitor

-0.222

Amikacinug/mL Amikacintranslation

-1.185

Cap5-10ug/mL Capreomycintranslation

-0.858

Rox10-50 ug/mL Roxithromycintranslation

0.059

SM2-5 ug/mL Streptomycintranslation

0.062

Tet5-10 ug/mL Tetracyclinetranslation

-0.838

Rif0.2-5ug/mL Rifampicintranscription

-0.167

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.916

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.393

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.034

CPZ10-50 ug/mL Chlorpromazinerespiration

0.999

Clofazimine10-13 ug/mL Clofaziminerespiration

0.148

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.389

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.141

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.123

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.228

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.151

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.024

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.833

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.699

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.934

KCN5-20 ug/mL Potassium cyaniderespiration

-0.005

NaN30.2-2 mM Sodium aziderespiration

-1.054

Nigericin50 uM Nigericinrespiration

-0.391

TRC10-150 ug/mL Triclosanrespiration

0.412

TRZ10-25 ug/mL Thioridazinerespiration

-0.191

Valinomycin0.5-10 uM Valinomycinrespiration

-0.706

ZnSO42 mM ZnSO4respiration

-0.138

menadione6-10 ug/mL Menadionerespiration

-0.018

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.976

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.463

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.446

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.437

NRP_1Non-replicating persistence stage 1dosRassociated

-0.263

Amp0.2mg/mL AmpicillincellWall

-0.094

Cephalexin20-100 ug/mL CephalexincellWall

-1.128

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.612

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.405

EMB10-20 ug/mL EthambutolcellWall

-0.631

Eta12-40 ug/mL EthionamidecellWall

-0.438

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.345

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.035

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.067

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.051

BZA0.12 mg/mL BenzamidearomaticAmides

0.071

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.573

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.852

H2O24 mM hydrogen peroxideDNAdamaging

-0.289

Levo10 ug/mL LevofloxacinDNAdamaging

0.091

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.200

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.081

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.291

UVUV-irradiationDNAdamaging

0.556

ARP41-4 ug/mL Antitubercular compound ARP4?

0.182

Antimycin12.5-50 ug/mL Antimycin A?

-0.280

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.658

PA_110-50 ug/mL Antitubercular compound PA-1?

0.170

PA_2110-50 ug/mL Antitubercular compound PA-21?

2.480

PA8240.2-2 ug/mL PA-824?

0.925

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.287

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.155

Verapamil50 uM Verapamil?

-0.958

mercaptoethanol2 mM 2-Mercaptoethanol?

0.165

methoxatin10-20 ug/mL Methoxatin?