from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0835/lpqQ

LFCtreatmentdescriptionclass of inhibitor

-0.631

Amikacinug/mL Amikacintranslation

0.199

Cap5-10ug/mL Capreomycintranslation

-0.697

Rox10-50 ug/mL Roxithromycintranslation

-0.666

SM2-5 ug/mL Streptomycintranslation

-0.173

Tet5-10 ug/mL Tetracyclinetranslation

-0.142

Rif0.2-5ug/mL Rifampicintranscription

0.033

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.601

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.107

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.829

CPZ10-50 ug/mL Chlorpromazinerespiration

1.555

Clofazimine10-13 ug/mL Clofaziminerespiration

0.524

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.311

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.395

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.197

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.091

Econazole10-24 ug/mL Econazole (azole drug)respiration

2.405

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

2.280

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.034

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.166

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.982

KCN5-20 ug/mL Potassium cyaniderespiration

-0.219

NaN30.2-2 mM Sodium aziderespiration

0.126

Nigericin50 uM Nigericinrespiration

-0.068

TRC10-150 ug/mL Triclosanrespiration

1.342

TRZ10-25 ug/mL Thioridazinerespiration

-0.791

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.299

menadione6-10 ug/mL Menadionerespiration

0.542

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.504

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.623

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.719

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.340

NRP_1Non-replicating persistence stage 1dosRassociated

0.003

Amp0.2mg/mL AmpicillincellWall

-0.604

Cephalexin20-100 ug/mL CephalexincellWall

0.179

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.659

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.078

EMB10-20 ug/mL EthambutolcellWall

-0.273

Eta12-40 ug/mL EthionamidecellWall

-0.176

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.145

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.340

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.372

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.431

BZA0.12 mg/mL BenzamidearomaticAmides

-0.434

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.523

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.022

H2O24 mM hydrogen peroxideDNAdamaging

-0.260

Levo10 ug/mL LevofloxacinDNAdamaging

-0.463

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.747

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.082

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.419

UVUV-irradiationDNAdamaging

0.353

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.111

Antimycin12.5-50 ug/mL Antimycin A?

-0.150

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.161

PA_110-50 ug/mL Antitubercular compound PA-1?

0.168

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.006

PA8240.2-2 ug/mL PA-824?

-0.267

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.029

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.984

Verapamil50 uM Verapamil?

-0.759

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.151

methoxatin10-20 ug/mL Methoxatin?