from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0834c/PE_PGRS14

LFCtreatmentdescriptionclass of inhibitor

0.721

Amikacinug/mL Amikacintranslation

0.154

Cap5-10ug/mL Capreomycintranslation

0.101

Rox10-50 ug/mL Roxithromycintranslation

-0.896

SM2-5 ug/mL Streptomycintranslation

0.486

Tet5-10 ug/mL Tetracyclinetranslation

0.028

Rif0.2-5ug/mL Rifampicintranscription

-0.781

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.641

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.530

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.414

CPZ10-50 ug/mL Chlorpromazinerespiration

0.664

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.147

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.089

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.742

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.608

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.256

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.195

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.958

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.068

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.259

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.761

KCN5-20 ug/mL Potassium cyaniderespiration

-0.046

NaN30.2-2 mM Sodium aziderespiration

-1.006

Nigericin50 uM Nigericinrespiration

0.934

TRC10-150 ug/mL Triclosanrespiration

1.628

TRZ10-25 ug/mL Thioridazinerespiration

1.038

Valinomycin0.5-10 uM Valinomycinrespiration

-0.731

ZnSO42 mM ZnSO4respiration

-0.369

menadione6-10 ug/mL Menadionerespiration

-0.029

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.962

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.290

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.219

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.098

NRP_1Non-replicating persistence stage 1dosRassociated

-0.865

Amp0.2mg/mL AmpicillincellWall

-0.581

Cephalexin20-100 ug/mL CephalexincellWall

-0.962

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.451

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.561

EMB10-20 ug/mL EthambutolcellWall

-0.871

Eta12-40 ug/mL EthionamidecellWall

-0.631

INH0.2-0.4 ug/mL IsoniazidcellWall

-1.076

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.378

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.203

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.978

BZA0.12 mg/mL BenzamidearomaticAmides

1.099

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.996

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.328

H2O24 mM hydrogen peroxideDNAdamaging

-0.200

Levo10 ug/mL LevofloxacinDNAdamaging

-0.692

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.101

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.556

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.847

UVUV-irradiationDNAdamaging

1.362

ARP41-4 ug/mL Antitubercular compound ARP4?

-1.069

Antimycin12.5-50 ug/mL Antimycin A?

-0.747

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.821

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.880

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.636

PA8240.2-2 ug/mL PA-824?

0.463

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.620

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.571

Verapamil50 uM Verapamil?

-0.798

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.038

methoxatin10-20 ug/mL Methoxatin?