from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0828c/-

LFCtreatmentdescriptionclass of inhibitor

0.132

Amikacinug/mL Amikacintranslation

0.552

Cap5-10ug/mL Capreomycintranslation

-0.262

Rox10-50 ug/mL Roxithromycintranslation

0.732

SM2-5 ug/mL Streptomycintranslation

0.578

Tet5-10 ug/mL Tetracyclinetranslation

0.729

Rif0.2-5ug/mL Rifampicintranscription

0.188

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.002

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.606

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.591

CPZ10-50 ug/mL Chlorpromazinerespiration

0.227

Clofazimine10-13 ug/mL Clofaziminerespiration

0.427

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.238

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.285

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.255

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.073

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.262

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.629

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.472

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.060

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.342

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.470

Nigericin50 uM Nigericinrespiration

-0.016

TRC10-150 ug/mL Triclosanrespiration

-0.994

TRZ10-25 ug/mL Thioridazinerespiration

-0.256

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.379

menadione6-10 ug/mL Menadionerespiration

-0.148

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.128

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.054

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.293

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.251

NRP_1Non-replicating persistence stage 1dosRassociated

-0.304

Amp0.2mg/mL AmpicillincellWall

-0.099

Cephalexin20-100 ug/mL CephalexincellWall

0.654

Cerulenin0.32-5 ug/mL CerulenincellWall

0.946

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.373

EMB10-20 ug/mL EthambutolcellWall

-0.088

Eta12-40 ug/mL EthionamidecellWall

-0.322

INH0.2-0.4 ug/mL IsoniazidcellWall

0.359

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.979

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.383

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.142

BZA0.12 mg/mL BenzamidearomaticAmides

0.124

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.472

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.956

H2O24 mM hydrogen peroxideDNAdamaging

0.094

Levo10 ug/mL LevofloxacinDNAdamaging

0.759

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.115

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.664

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.428

UVUV-irradiationDNAdamaging

-0.334

ARP41-4 ug/mL Antitubercular compound ARP4?

0.297

Antimycin12.5-50 ug/mL Antimycin A?

-0.436

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.598

PA_110-50 ug/mL Antitubercular compound PA-1?

0.361

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.821

PA8240.2-2 ug/mL PA-824?

-0.501

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.411

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.734

Verapamil50 uM Verapamil?

-0.751

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.257

methoxatin10-20 ug/mL Methoxatin?