from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0821c/phoY2

LFCtreatmentdescriptionclass of inhibitor

-1.125

Amikacinug/mL Amikacintranslation

-0.601

Cap5-10ug/mL Capreomycintranslation

-1.203

Rox10-50 ug/mL Roxithromycintranslation

-0.962

SM2-5 ug/mL Streptomycintranslation

-0.073

Tet5-10 ug/mL Tetracyclinetranslation

-0.723

Rif0.2-5ug/mL Rifampicintranscription

-0.190

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.081

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.125

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.976

CPZ10-50 ug/mL Chlorpromazinerespiration

0.482

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.066

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.121

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.959

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.441

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.112

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.926

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

2.317

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.772

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.354

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.031

KCN5-20 ug/mL Potassium cyaniderespiration

0.264

NaN30.2-2 mM Sodium aziderespiration

-0.461

Nigericin50 uM Nigericinrespiration

0.647

TRC10-150 ug/mL Triclosanrespiration

0.435

TRZ10-25 ug/mL Thioridazinerespiration

-1.024

Valinomycin0.5-10 uM Valinomycinrespiration

-0.367

ZnSO42 mM ZnSO4respiration

-0.082

menadione6-10 ug/mL Menadionerespiration

0.564

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.563

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.174

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.507

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.010

NRP_1Non-replicating persistence stage 1dosRassociated

-0.455

Amp0.2mg/mL AmpicillincellWall

-0.065

Cephalexin20-100 ug/mL CephalexincellWall

-0.855

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.166

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.467

EMB10-20 ug/mL EthambutolcellWall

-0.241

Eta12-40 ug/mL EthionamidecellWall

-0.296

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.269

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.623

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.727

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.310

BZA0.12 mg/mL BenzamidearomaticAmides

0.216

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.223

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.060

H2O24 mM hydrogen peroxideDNAdamaging

0.191

Levo10 ug/mL LevofloxacinDNAdamaging

-0.992

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.832

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.052

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.931

UVUV-irradiationDNAdamaging

-1.893

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.393

Antimycin12.5-50 ug/mL Antimycin A?

-0.643

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.129

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.328

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.689

PA8240.2-2 ug/mL PA-824?

0.190

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.204

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.382

Verapamil50 uM Verapamil?

-0.357

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.739

methoxatin10-20 ug/mL Methoxatin?