from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0807/-

LFCtreatmentdescriptionclass of inhibitor

0.772

Amikacinug/mL Amikacintranslation

0.038

Cap5-10ug/mL Capreomycintranslation

1.046

Rox10-50 ug/mL Roxithromycintranslation

-0.286

SM2-5 ug/mL Streptomycintranslation

1.588

Tet5-10 ug/mL Tetracyclinetranslation

0.111

Rif0.2-5ug/mL Rifampicintranscription

-0.571

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.432

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.242

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.342

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

6.597

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.967

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.217

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.027

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.977

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.678

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.855

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.034

Nigericin50 uM Nigericinrespiration

1.531

TRC10-150 ug/mL Triclosanrespiration

1.779

TRZ10-25 ug/mL Thioridazinerespiration

-0.844

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.023

menadione6-10 ug/mL Menadionerespiration

-0.166

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.315

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.252

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.882

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.201

NRP_1Non-replicating persistence stage 1dosRassociated

-0.452

Amp0.2mg/mL AmpicillincellWall

0.853

Cephalexin20-100 ug/mL CephalexincellWall

-0.455

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.403

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.053

EMB10-20 ug/mL EthambutolcellWall

0.269

Eta12-40 ug/mL EthionamidecellWall

0.268

INH0.2-0.4 ug/mL IsoniazidcellWall

0.161

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.876

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.449

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.492

BZA0.12 mg/mL BenzamidearomaticAmides

-0.672

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.068

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.603

H2O24 mM hydrogen peroxideDNAdamaging

0.175

Levo10 ug/mL LevofloxacinDNAdamaging

-0.952

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.227

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.147

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.603

UVUV-irradiationDNAdamaging

1.240

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.033

Antimycin12.5-50 ug/mL Antimycin A?

-1.409

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.128

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.121

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.291

PA8240.2-2 ug/mL PA-824?

0.571

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.206

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.786

Verapamil50 uM Verapamil?

-0.872

mercaptoethanol2 mM 2-Mercaptoethanol?

0.519

methoxatin10-20 ug/mL Methoxatin?