from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0804/-

LFCtreatmentdescriptionclass of inhibitor

0.018

Amikacinug/mL Amikacintranslation

-0.931

Cap5-10ug/mL Capreomycintranslation

-0.888

Rox10-50 ug/mL Roxithromycintranslation

-0.327

SM2-5 ug/mL Streptomycintranslation

-0.631

Tet5-10 ug/mL Tetracyclinetranslation

0.785

Rif0.2-5ug/mL Rifampicintranscription

-0.345

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.423

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.515

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.129

CPZ10-50 ug/mL Chlorpromazinerespiration

0.078

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.136

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.234

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.420

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.866

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.395

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.291

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.170

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.012

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.189

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.506

KCN5-20 ug/mL Potassium cyaniderespiration

0.294

NaN30.2-2 mM Sodium aziderespiration

-0.094

Nigericin50 uM Nigericinrespiration

0.053

TRC10-150 ug/mL Triclosanrespiration

1.125

TRZ10-25 ug/mL Thioridazinerespiration

-1.960

Valinomycin0.5-10 uM Valinomycinrespiration

-0.271

ZnSO42 mM ZnSO4respiration

0.398

menadione6-10 ug/mL Menadionerespiration

0.020

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.218

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.091

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.431

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.261

NRP_1Non-replicating persistence stage 1dosRassociated

-0.154

Amp0.2mg/mL AmpicillincellWall

0.389

Cephalexin20-100 ug/mL CephalexincellWall

-0.177

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.729

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.204

EMB10-20 ug/mL EthambutolcellWall

0.279

Eta12-40 ug/mL EthionamidecellWall

0.604

INH0.2-0.4 ug/mL IsoniazidcellWall

0.121

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.043

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.666

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.161

BZA0.12 mg/mL BenzamidearomaticAmides

-0.009

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.378

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.256

H2O24 mM hydrogen peroxideDNAdamaging

-0.189

Levo10 ug/mL LevofloxacinDNAdamaging

-0.807

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.791

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.316

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.926

UVUV-irradiationDNAdamaging

1.398

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.041

Antimycin12.5-50 ug/mL Antimycin A?

-0.404

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.481

PA_110-50 ug/mL Antitubercular compound PA-1?

0.153

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.829

PA8240.2-2 ug/mL PA-824?

0.785

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

1.472

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.220

Verapamil50 uM Verapamil?

-0.093

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.463

methoxatin10-20 ug/mL Methoxatin?