from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0800/pepC

LFCtreatmentdescriptionclass of inhibitor

-0.290

Amikacinug/mL Amikacintranslation

-0.843

Cap5-10ug/mL Capreomycintranslation

-0.733

Rox10-50 ug/mL Roxithromycintranslation

-0.397

SM2-5 ug/mL Streptomycintranslation

-0.633

Tet5-10 ug/mL Tetracyclinetranslation

0.805

Rif0.2-5ug/mL Rifampicintranscription

-0.333

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.749

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.384

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.156

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.232

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.342

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.933

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.528

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.161

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.954

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.361

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.054

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.795

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.318

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.091

KCN5-20 ug/mL Potassium cyaniderespiration

-0.243

NaN30.2-2 mM Sodium aziderespiration

-0.790

Nigericin50 uM Nigericinrespiration

0.725

TRC10-150 ug/mL Triclosanrespiration

-0.320

TRZ10-25 ug/mL Thioridazinerespiration

-1.398

Valinomycin0.5-10 uM Valinomycinrespiration

-0.491

ZnSO42 mM ZnSO4respiration

0.474

menadione6-10 ug/mL Menadionerespiration

-0.171

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.170

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.543

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.397

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.479

NRP_1Non-replicating persistence stage 1dosRassociated

-0.262

Amp0.2mg/mL AmpicillincellWall

-0.251

Cephalexin20-100 ug/mL CephalexincellWall

-0.474

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.103

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.098

EMB10-20 ug/mL EthambutolcellWall

-0.524

Eta12-40 ug/mL EthionamidecellWall

-0.853

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.021

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-2.008

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.647

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.172

BZA0.12 mg/mL BenzamidearomaticAmides

0.849

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.503

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.313

H2O24 mM hydrogen peroxideDNAdamaging

-0.258

Levo10 ug/mL LevofloxacinDNAdamaging

0.089

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.117

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.078

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.200

UVUV-irradiationDNAdamaging

0.331

ARP41-4 ug/mL Antitubercular compound ARP4?

0.235

Antimycin12.5-50 ug/mL Antimycin A?

-0.618

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.380

PA_110-50 ug/mL Antitubercular compound PA-1?

0.169

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.397

PA8240.2-2 ug/mL PA-824?

0.529

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.636

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.248

Verapamil50 uM Verapamil?

-0.841

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.954

methoxatin10-20 ug/mL Methoxatin?