from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0799c/-

LFCtreatmentdescriptionclass of inhibitor

-0.387

Amikacinug/mL Amikacintranslation

-0.427

Cap5-10ug/mL Capreomycintranslation

-1.131

Rox10-50 ug/mL Roxithromycintranslation

-0.672

SM2-5 ug/mL Streptomycintranslation

-3.479

Tet5-10 ug/mL Tetracyclinetranslation

-0.068

Rif0.2-5ug/mL Rifampicintranscription

-0.156

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.267

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.393

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.222

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.251

Clofazimine10-13 ug/mL Clofaziminerespiration

0.279

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.901

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.810

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.083

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.320

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.639

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.800

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.223

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.557

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.121

KCN5-20 ug/mL Potassium cyaniderespiration

1.068

NaN30.2-2 mM Sodium aziderespiration

0.242

Nigericin50 uM Nigericinrespiration

-1.182

TRC10-150 ug/mL Triclosanrespiration

-1.272

TRZ10-25 ug/mL Thioridazinerespiration

-2.076

Valinomycin0.5-10 uM Valinomycinrespiration

1.314

ZnSO42 mM ZnSO4respiration

-0.673

menadione6-10 ug/mL Menadionerespiration

0.163

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.624

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.104

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.025

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.091

NRP_1Non-replicating persistence stage 1dosRassociated

0.160

Amp0.2mg/mL AmpicillincellWall

0.525

Cephalexin20-100 ug/mL CephalexincellWall

0.560

Cerulenin0.32-5 ug/mL CerulenincellWall

0.647

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.185

EMB10-20 ug/mL EthambutolcellWall

0.687

Eta12-40 ug/mL EthionamidecellWall

0.913

INH0.2-0.4 ug/mL IsoniazidcellWall

0.419

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.443

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.673

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.234

BZA0.12 mg/mL BenzamidearomaticAmides

0.528

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.600

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.447

H2O24 mM hydrogen peroxideDNAdamaging

0.376

Levo10 ug/mL LevofloxacinDNAdamaging

0.589

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.493

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.181

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.061

UVUV-irradiationDNAdamaging

-0.495

ARP41-4 ug/mL Antitubercular compound ARP4?

0.475

Antimycin12.5-50 ug/mL Antimycin A?

0.745

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.527

PA_110-50 ug/mL Antitubercular compound PA-1?

0.436

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.505

PA8240.2-2 ug/mL PA-824?

0.166

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.562

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.207

mercaptoethanol2 mM 2-Mercaptoethanol?

0.436

methoxatin10-20 ug/mL Methoxatin?