from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0797/-

LFCtreatmentdescriptionclass of inhibitor

0.484

Amikacinug/mL Amikacintranslation

-0.505

Cap5-10ug/mL Capreomycintranslation

0.801

Rox10-50 ug/mL Roxithromycintranslation

-0.174

SM2-5 ug/mL Streptomycintranslation

-0.880

Tet5-10 ug/mL Tetracyclinetranslation

0.754

Rif0.2-5ug/mL Rifampicintranscription

0.187

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.027

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.605

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.276

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.034

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.351

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.292

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.628

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.115

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.558

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.057

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.153

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.785

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.166

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.031

KCN5-20 ug/mL Potassium cyaniderespiration

1.297

NaN30.2-2 mM Sodium aziderespiration

-0.071

Nigericin50 uM Nigericinrespiration

-0.236

TRC10-150 ug/mL Triclosanrespiration

-1.001

TRZ10-25 ug/mL Thioridazinerespiration

0.056

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.414

menadione6-10 ug/mL Menadionerespiration

0.115

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.161

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.201

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.620

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.944

NRP_1Non-replicating persistence stage 1dosRassociated

-0.665

Amp0.2mg/mL AmpicillincellWall

-0.221

Cephalexin20-100 ug/mL CephalexincellWall

0.394

Cerulenin0.32-5 ug/mL CerulenincellWall

0.768

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.137

EMB10-20 ug/mL EthambutolcellWall

-0.043

Eta12-40 ug/mL EthionamidecellWall

-0.205

INH0.2-0.4 ug/mL IsoniazidcellWall

0.112

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.407

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.574

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.930

BZA0.12 mg/mL BenzamidearomaticAmides

0.639

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.708

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.025

H2O24 mM hydrogen peroxideDNAdamaging

0.063

Levo10 ug/mL LevofloxacinDNAdamaging

-0.182

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.947

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.031

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.016

UVUV-irradiationDNAdamaging

-0.512

ARP41-4 ug/mL Antitubercular compound ARP4?

0.062

Antimycin12.5-50 ug/mL Antimycin A?

0.463

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.242

PA_110-50 ug/mL Antitubercular compound PA-1?

0.366

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.027

PA8240.2-2 ug/mL PA-824?

-0.087

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.101

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.459

Verapamil50 uM Verapamil?

0.071

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.000

methoxatin10-20 ug/mL Methoxatin?