from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0796/-

LFCtreatmentdescriptionclass of inhibitor

-0.384

Amikacinug/mL Amikacintranslation

0.365

Cap5-10ug/mL Capreomycintranslation

0.082

Rox10-50 ug/mL Roxithromycintranslation

-0.360

SM2-5 ug/mL Streptomycintranslation

-0.471

Tet5-10 ug/mL Tetracyclinetranslation

0.062

Rif0.2-5ug/mL Rifampicintranscription

-0.911

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.493

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.112

CPZ10-50 ug/mL Chlorpromazinerespiration

1.246

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.032

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.347

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.113

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.299

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.541

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.435

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.313

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.150

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.170

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.484

KCN5-20 ug/mL Potassium cyaniderespiration

1.549

NaN30.2-2 mM Sodium aziderespiration

-0.476

Nigericin50 uM Nigericinrespiration

-0.116

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.488

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.711

menadione6-10 ug/mL Menadionerespiration

-0.225

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.125

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.095

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.315

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.117

NRP_1Non-replicating persistence stage 1dosRassociated

-1.069

Amp0.2mg/mL AmpicillincellWall

0.289

Cephalexin20-100 ug/mL CephalexincellWall

0.057

Cerulenin0.32-5 ug/mL CerulenincellWall

0.235

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.283

EMB10-20 ug/mL EthambutolcellWall

-0.393

Eta12-40 ug/mL EthionamidecellWall

-0.495

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.422

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.290

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.115

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.569

BZA0.12 mg/mL BenzamidearomaticAmides

-0.605

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.218

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.170

H2O24 mM hydrogen peroxideDNAdamaging

-0.208

Levo10 ug/mL LevofloxacinDNAdamaging

0.073

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.136

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.288

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.231

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.349

Antimycin12.5-50 ug/mL Antimycin A?

-1.076

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.407

PA_110-50 ug/mL Antitubercular compound PA-1?

0.742

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.315

PA8240.2-2 ug/mL PA-824?

-0.903

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.264

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.162

Verapamil50 uM Verapamil?

-2.347

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.199

methoxatin10-20 ug/mL Methoxatin?