from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0783c/emrB

LFCtreatmentdescriptionclass of inhibitor

-1.657

Amikacinug/mL Amikacintranslation

-0.823

Cap5-10ug/mL Capreomycintranslation

-1.727

Rox10-50 ug/mL Roxithromycintranslation

-0.749

SM2-5 ug/mL Streptomycintranslation

-4.354

Tet5-10 ug/mL Tetracyclinetranslation

1.118

Rif0.2-5ug/mL Rifampicintranscription

0.333

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.529

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.965

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.179

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.227

Clofazimine10-13 ug/mL Clofaziminerespiration

0.367

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.180

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.124

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.771

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.181

Econazole10-24 ug/mL Econazole (azole drug)respiration

-2.339

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.139

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.334

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.019

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.029

KCN5-20 ug/mL Potassium cyaniderespiration

-0.042

NaN30.2-2 mM Sodium aziderespiration

0.503

Nigericin50 uM Nigericinrespiration

-0.261

TRC10-150 ug/mL Triclosanrespiration

0.619

TRZ10-25 ug/mL Thioridazinerespiration

-1.880

Valinomycin0.5-10 uM Valinomycinrespiration

1.380

ZnSO42 mM ZnSO4respiration

-0.750

menadione6-10 ug/mL Menadionerespiration

0.274

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.532

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.118

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.952

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.919

NRP_1Non-replicating persistence stage 1dosRassociated

0.226

Amp0.2mg/mL AmpicillincellWall

-0.155

Cephalexin20-100 ug/mL CephalexincellWall

0.328

Cerulenin0.32-5 ug/mL CerulenincellWall

0.534

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.630

EMB10-20 ug/mL EthambutolcellWall

0.645

Eta12-40 ug/mL EthionamidecellWall

0.953

INH0.2-0.4 ug/mL IsoniazidcellWall

0.392

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.261

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.787

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.002

BZA0.12 mg/mL BenzamidearomaticAmides

0.013

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.018

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.450

H2O24 mM hydrogen peroxideDNAdamaging

0.133

Levo10 ug/mL LevofloxacinDNAdamaging

-0.084

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.004

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.110

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.087

UVUV-irradiationDNAdamaging

-0.622

ARP41-4 ug/mL Antitubercular compound ARP4?

0.372

Antimycin12.5-50 ug/mL Antimycin A?

0.445

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.186

PA_110-50 ug/mL Antitubercular compound PA-1?

1.006

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.094

PA8240.2-2 ug/mL PA-824?

0.495

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.297

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.566

Verapamil50 uM Verapamil?

0.251

mercaptoethanol2 mM 2-Mercaptoethanol?

0.602

methoxatin10-20 ug/mL Methoxatin?