from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0779c/-

LFCtreatmentdescriptionclass of inhibitor

0.838

Amikacinug/mL Amikacintranslation

0.312

Cap5-10ug/mL Capreomycintranslation

0.268

Rox10-50 ug/mL Roxithromycintranslation

-0.595

SM2-5 ug/mL Streptomycintranslation

-0.435

Tet5-10 ug/mL Tetracyclinetranslation

0.681

Rif0.2-5ug/mL Rifampicintranscription

0.005

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.864

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.470

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.492

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.519

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.510

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.812

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.656

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.418

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.532

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.974

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.412

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.690

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.840

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.295

KCN5-20 ug/mL Potassium cyaniderespiration

-0.354

NaN30.2-2 mM Sodium aziderespiration

-0.432

Nigericin50 uM Nigericinrespiration

-0.379

TRC10-150 ug/mL Triclosanrespiration

-0.502

TRZ10-25 ug/mL Thioridazinerespiration

1.758

Valinomycin0.5-10 uM Valinomycinrespiration

0.096

ZnSO42 mM ZnSO4respiration

0.638

menadione6-10 ug/mL Menadionerespiration

-0.874

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.399

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.359

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.490

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.396

NRP_1Non-replicating persistence stage 1dosRassociated

-0.216

Amp0.2mg/mL AmpicillincellWall

0.274

Cephalexin20-100 ug/mL CephalexincellWall

0.618

Cerulenin0.32-5 ug/mL CerulenincellWall

0.174

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.472

EMB10-20 ug/mL EthambutolcellWall

-0.378

Eta12-40 ug/mL EthionamidecellWall

-0.094

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.044

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.579

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.977

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.660

BZA0.12 mg/mL BenzamidearomaticAmides

0.494

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.805

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.133

H2O24 mM hydrogen peroxideDNAdamaging

0.236

Levo10 ug/mL LevofloxacinDNAdamaging

0.018

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.834

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.519

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.205

UVUV-irradiationDNAdamaging

1.670

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.099

Antimycin12.5-50 ug/mL Antimycin A?

-0.506

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.222

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.060

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.371

PA8240.2-2 ug/mL PA-824?

-0.508

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.017

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.549

Verapamil50 uM Verapamil?

0.098

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.452

methoxatin10-20 ug/mL Methoxatin?