from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0777/purB

LFCtreatmentdescriptionclass of inhibitor

-0.831

Amikacinug/mL Amikacintranslation

-0.484

Cap5-10ug/mL Capreomycintranslation

-0.287

Rox10-50 ug/mL Roxithromycintranslation

-0.838

SM2-5 ug/mL Streptomycintranslation

-2.299

Tet5-10 ug/mL Tetracyclinetranslation

1.285

Rif0.2-5ug/mL Rifampicintranscription

-0.267

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.121

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.091

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.705

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.641

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.331

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.610

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.935

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.593

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.259

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.626

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.461

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.585

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.917

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.030

KCN5-20 ug/mL Potassium cyaniderespiration

0.415

NaN30.2-2 mM Sodium aziderespiration

-0.207

Nigericin50 uM Nigericinrespiration

-0.329

TRC10-150 ug/mL Triclosanrespiration

-0.273

TRZ10-25 ug/mL Thioridazinerespiration

-2.762

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.179

menadione6-10 ug/mL Menadionerespiration

0.355

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.072

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.219

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.127

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.122

NRP_1Non-replicating persistence stage 1dosRassociated

0.118

Amp0.2mg/mL AmpicillincellWall

0.433

Cephalexin20-100 ug/mL CephalexincellWall

-0.043

Cerulenin0.32-5 ug/mL CerulenincellWall

0.577

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.176

EMB10-20 ug/mL EthambutolcellWall

0.463

Eta12-40 ug/mL EthionamidecellWall

0.308

INH0.2-0.4 ug/mL IsoniazidcellWall

0.409

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.644

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.347

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.403

BZA0.12 mg/mL BenzamidearomaticAmides

0.108

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.058

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.381

H2O24 mM hydrogen peroxideDNAdamaging

0.392

Levo10 ug/mL LevofloxacinDNAdamaging

-0.243

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.020

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.360

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.395

UVUV-irradiationDNAdamaging

-0.325

ARP41-4 ug/mL Antitubercular compound ARP4?

0.064

Antimycin12.5-50 ug/mL Antimycin A?

-0.655

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.302

PA_110-50 ug/mL Antitubercular compound PA-1?

0.046

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.197

PA8240.2-2 ug/mL PA-824?

0.207

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.168

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.014

Verapamil50 uM Verapamil?

-0.984

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.688

methoxatin10-20 ug/mL Methoxatin?