from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0763c/-

LFCtreatmentdescriptionclass of inhibitor

0.639

Amikacinug/mL Amikacintranslation

-0.280

Cap5-10ug/mL Capreomycintranslation

0.172

Rox10-50 ug/mL Roxithromycintranslation

0.735

SM2-5 ug/mL Streptomycintranslation

1.030

Tet5-10 ug/mL Tetracyclinetranslation

-0.037

Rif0.2-5ug/mL Rifampicintranscription

-0.363

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.616

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.498

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.032

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.263

Clofazimine10-13 ug/mL Clofaziminerespiration

0.234

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.838

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.031

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.683

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.725

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.190

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.355

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.728

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.380

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.545

KCN5-20 ug/mL Potassium cyaniderespiration

-1.190

NaN30.2-2 mM Sodium aziderespiration

0.451

Nigericin50 uM Nigericinrespiration

0.533

TRC10-150 ug/mL Triclosanrespiration

1.203

TRZ10-25 ug/mL Thioridazinerespiration

-1.622

Valinomycin0.5-10 uM Valinomycinrespiration

-1.928

ZnSO42 mM ZnSO4respiration

-0.080

menadione6-10 ug/mL Menadionerespiration

-0.143

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.226

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.576

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.295

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.066

NRP_1Non-replicating persistence stage 1dosRassociated

-0.546

Amp0.2mg/mL AmpicillincellWall

-0.839

Cephalexin20-100 ug/mL CephalexincellWall

-0.252

Cerulenin0.32-5 ug/mL CerulenincellWall

0.584

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.181

EMB10-20 ug/mL EthambutolcellWall

0.606

Eta12-40 ug/mL EthionamidecellWall

-0.885

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.440

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.057

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.219

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.088

BZA0.12 mg/mL BenzamidearomaticAmides

0.095

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.241

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.198

H2O24 mM hydrogen peroxideDNAdamaging

-0.317

Levo10 ug/mL LevofloxacinDNAdamaging

0.193

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.399

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.257

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.130

UVUV-irradiationDNAdamaging

0.308

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.448

Antimycin12.5-50 ug/mL Antimycin A?

0.012

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.577

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.543

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.875

PA8240.2-2 ug/mL PA-824?

0.538

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.335

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.338

Verapamil50 uM Verapamil?

0.055

mercaptoethanol2 mM 2-Mercaptoethanol?

0.141

methoxatin10-20 ug/mL Methoxatin?