from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0759c/-

LFCtreatmentdescriptionclass of inhibitor

-0.752

Amikacinug/mL Amikacintranslation

-0.577

Cap5-10ug/mL Capreomycintranslation

-0.384

Rox10-50 ug/mL Roxithromycintranslation

0.667

SM2-5 ug/mL Streptomycintranslation

-0.344

Tet5-10 ug/mL Tetracyclinetranslation

-1.578

Rif0.2-5ug/mL Rifampicintranscription

-0.194

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.179

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.862

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.703

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.566

Clofazimine10-13 ug/mL Clofaziminerespiration

0.820

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.771

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.182

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.877

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.628

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.469

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.285

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.036

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.065

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.173

KCN5-20 ug/mL Potassium cyaniderespiration

0.068

NaN30.2-2 mM Sodium aziderespiration

1.452

Nigericin50 uM Nigericinrespiration

-0.886

TRC10-150 ug/mL Triclosanrespiration

-2.065

TRZ10-25 ug/mL Thioridazinerespiration

-2.021

Valinomycin0.5-10 uM Valinomycinrespiration

1.699

ZnSO42 mM ZnSO4respiration

1.358

menadione6-10 ug/mL Menadionerespiration

-0.186

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.558

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.288

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.037

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.068

NRP_1Non-replicating persistence stage 1dosRassociated

0.975

Amp0.2mg/mL AmpicillincellWall

0.496

Cephalexin20-100 ug/mL CephalexincellWall

0.448

Cerulenin0.32-5 ug/mL CerulenincellWall

0.650

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.364

EMB10-20 ug/mL EthambutolcellWall

0.736

Eta12-40 ug/mL EthionamidecellWall

-0.110

INH0.2-0.4 ug/mL IsoniazidcellWall

0.360

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.366

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.406

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.021

BZA0.12 mg/mL BenzamidearomaticAmides

-0.064

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.144

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.364

H2O24 mM hydrogen peroxideDNAdamaging

-0.913

Levo10 ug/mL LevofloxacinDNAdamaging

0.483

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.011

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.451

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.143

UVUV-irradiationDNAdamaging

1.871

ARP41-4 ug/mL Antitubercular compound ARP4?

0.741

Antimycin12.5-50 ug/mL Antimycin A?

0.815

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.678

PA_110-50 ug/mL Antitubercular compound PA-1?

0.696

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.096

PA8240.2-2 ug/mL PA-824?

-1.095

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.208

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.605

Verapamil50 uM Verapamil?

1.004

mercaptoethanol2 mM 2-Mercaptoethanol?

1.953

methoxatin10-20 ug/mL Methoxatin?