from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0752c/fadE9

LFCtreatmentdescriptionclass of inhibitor

-0.706

Amikacinug/mL Amikacintranslation

-0.673

Cap5-10ug/mL Capreomycintranslation

-0.406

Rox10-50 ug/mL Roxithromycintranslation

0.849

SM2-5 ug/mL Streptomycintranslation

-1.104

Tet5-10 ug/mL Tetracyclinetranslation

0.008

Rif0.2-5ug/mL Rifampicintranscription

-0.676

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.037

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.437

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.056

CPZ10-50 ug/mL Chlorpromazinerespiration

0.245

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.048

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.526

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

4.040

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.209

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.538

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.125

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.286

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.581

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.005

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.436

KCN5-20 ug/mL Potassium cyaniderespiration

-0.427

NaN30.2-2 mM Sodium aziderespiration

-2.232

Nigericin50 uM Nigericinrespiration

0.079

TRC10-150 ug/mL Triclosanrespiration

0.187

TRZ10-25 ug/mL Thioridazinerespiration

1.553

Valinomycin0.5-10 uM Valinomycinrespiration

-0.286

ZnSO42 mM ZnSO4respiration

0.019

menadione6-10 ug/mL Menadionerespiration

0.189

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.853

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.553

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.013

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.098

NRP_1Non-replicating persistence stage 1dosRassociated

-0.499

Amp0.2mg/mL AmpicillincellWall

-0.559

Cephalexin20-100 ug/mL CephalexincellWall

-1.146

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.366

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.489

EMB10-20 ug/mL EthambutolcellWall

-1.195

Eta12-40 ug/mL EthionamidecellWall

-1.154

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.627

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.295

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.120

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.021

BZA0.12 mg/mL BenzamidearomaticAmides

0.816

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.164

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.561

H2O24 mM hydrogen peroxideDNAdamaging

-0.036

Levo10 ug/mL LevofloxacinDNAdamaging

0.104

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.734

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.454

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.347

UVUV-irradiationDNAdamaging

0.544

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.038

Antimycin12.5-50 ug/mL Antimycin A?

-1.389

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.038

PA_110-50 ug/mL Antitubercular compound PA-1?

0.010

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.174

PA8240.2-2 ug/mL PA-824?

0.238

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.159

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.762

Verapamil50 uM Verapamil?

-1.436

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.843

methoxatin10-20 ug/mL Methoxatin?