from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0744c/-

LFCtreatmentdescriptionclass of inhibitor

2.373

Amikacinug/mL Amikacintranslation

1.253

Cap5-10ug/mL Capreomycintranslation

2.738

Rox10-50 ug/mL Roxithromycintranslation

0.815

SM2-5 ug/mL Streptomycintranslation

1.369

Tet5-10 ug/mL Tetracyclinetranslation

-0.637

Rif0.2-5ug/mL Rifampicintranscription

-0.458

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.073

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.906

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.929

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.905

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.888

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.315

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.857

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.616

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.138

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

1.078

NaN30.2-2 mM Sodium aziderespiration

0.368

Nigericin50 uM Nigericinrespiration

-0.350

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.008

Valinomycin0.5-10 uM Valinomycinrespiration

5.177

ZnSO42 mM ZnSO4respiration

1.680

menadione6-10 ug/mL Menadionerespiration

-0.264

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.379

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.091

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.870

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.978

NRP_1Non-replicating persistence stage 1dosRassociated

-0.371

Amp0.2mg/mL AmpicillincellWall

-0.253

Cephalexin20-100 ug/mL CephalexincellWall

0.273

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.236

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.193

EMB10-20 ug/mL EthambutolcellWall

-0.493

Eta12-40 ug/mL EthionamidecellWall

-0.490

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.490

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.054

BZA0.12 mg/mL BenzamidearomaticAmides

-0.013

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.042

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.580

H2O24 mM hydrogen peroxideDNAdamaging

-0.370

Levo10 ug/mL LevofloxacinDNAdamaging

-0.004

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.608

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.150

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

0.134

Antimycin12.5-50 ug/mL Antimycin A?

-0.643

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.316

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.389

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.272

PA8240.2-2 ug/mL PA-824?

-0.691

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.823

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.612

Verapamil50 uM Verapamil?

-2.775

mercaptoethanol2 mM 2-Mercaptoethanol?

1.603

methoxatin10-20 ug/mL Methoxatin?