from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0736/rslA

LFCtreatmentdescriptionclass of inhibitor

-0.138

Amikacinug/mL Amikacintranslation

0.104

Cap5-10ug/mL Capreomycintranslation

1.311

Rox10-50 ug/mL Roxithromycintranslation

-0.610

SM2-5 ug/mL Streptomycintranslation

0.877

Tet5-10 ug/mL Tetracyclinetranslation

0.674

Rif0.2-5ug/mL Rifampicintranscription

-0.282

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.150

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.312

CPZ10-50 ug/mL Chlorpromazinerespiration

1.080

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.755

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

7.074

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.730

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.852

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.951

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.025

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.011

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.530

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.279

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.683

Nigericin50 uM Nigericinrespiration

0.939

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.367

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.228

menadione6-10 ug/mL Menadionerespiration

0.157

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.434

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.182

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.769

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.358

NRP_1Non-replicating persistence stage 1dosRassociated

-0.911

Amp0.2mg/mL AmpicillincellWall

-0.149

Cephalexin20-100 ug/mL CephalexincellWall

-0.750

Cerulenin0.32-5 ug/mL CerulenincellWall

0.679

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.055

EMB10-20 ug/mL EthambutolcellWall

-1.227

Eta12-40 ug/mL EthionamidecellWall

-1.355

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.392

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.579

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.110

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.659

BZA0.12 mg/mL BenzamidearomaticAmides

0.776

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.042

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.375

H2O24 mM hydrogen peroxideDNAdamaging

-0.922

Levo10 ug/mL LevofloxacinDNAdamaging

-0.062

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.684

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.714

UVUV-irradiationDNAdamaging

0.839

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.648

Antimycin12.5-50 ug/mL Antimycin A?

-1.854

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.693

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.705

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.586

PA8240.2-2 ug/mL PA-824?

0.679

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.347

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.487

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.203

methoxatin10-20 ug/mL Methoxatin?