from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0712/-

LFCtreatmentdescriptionclass of inhibitor

-0.748

Amikacinug/mL Amikacintranslation

-0.367

Cap5-10ug/mL Capreomycintranslation

-0.767

Rox10-50 ug/mL Roxithromycintranslation

0.141

SM2-5 ug/mL Streptomycintranslation

-1.364

Tet5-10 ug/mL Tetracyclinetranslation

-0.809

Rif0.2-5ug/mL Rifampicintranscription

-0.732

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.751

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.297

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.262

CPZ10-50 ug/mL Chlorpromazinerespiration

0.879

Clofazimine10-13 ug/mL Clofaziminerespiration

0.343

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.655

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.124

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.544

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.212

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.244

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.294

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.792

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.426

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.381

KCN5-20 ug/mL Potassium cyaniderespiration

-0.580

NaN30.2-2 mM Sodium aziderespiration

0.777

Nigericin50 uM Nigericinrespiration

1.596

TRC10-150 ug/mL Triclosanrespiration

1.251

TRZ10-25 ug/mL Thioridazinerespiration

-0.300

Valinomycin0.5-10 uM Valinomycinrespiration

0.398

ZnSO42 mM ZnSO4respiration

-0.267

menadione6-10 ug/mL Menadionerespiration

0.032

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.364

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.350

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.187

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.134

NRP_1Non-replicating persistence stage 1dosRassociated

-0.285

Amp0.2mg/mL AmpicillincellWall

-0.397

Cephalexin20-100 ug/mL CephalexincellWall

-0.391

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.022

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.680

EMB10-20 ug/mL EthambutolcellWall

-1.048

Eta12-40 ug/mL EthionamidecellWall

-0.795

INH0.2-0.4 ug/mL IsoniazidcellWall

0.009

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.254

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.348

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.642

BZA0.12 mg/mL BenzamidearomaticAmides

-0.242

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.138

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.327

H2O24 mM hydrogen peroxideDNAdamaging

-0.680

Levo10 ug/mL LevofloxacinDNAdamaging

-0.331

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.904

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.882

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.049

UVUV-irradiationDNAdamaging

1.649

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.381

Antimycin12.5-50 ug/mL Antimycin A?

0.058

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.761

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.689

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.950

PA8240.2-2 ug/mL PA-824?

1.605

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.697

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.352

Verapamil50 uM Verapamil?

0.536

mercaptoethanol2 mM 2-Mercaptoethanol?

0.093

methoxatin10-20 ug/mL Methoxatin?